LCOR

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LCOR
Protein LCOR PDB 2cob.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases LCOR, MLR2, ligand dependent nuclear receptor corepressor, C10orf12
External IDs HomoloGene: 22914 GeneCards: LCOR
Gene location (Human)
Chromosome 10 (human)
Chr. Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for LCOR
Genomic location for LCOR
Band 10q24.1 Start 96,832,282 bp[1]
End 96,995,959 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001170765
NM_001170766
NM_001346516
NM_015652
NM_032440

n/a

RefSeq (protein)

NP_001164236
NP_001164237
NP_001333445
NP_115816

n/a

Location (UCSC) Chr 10: 96.83 – 97 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.[3][4][5]

Function[edit]

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196233 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell. 11 (1): 139–50. doi:10.1016/S1097-2765(03)00014-5. PMID 12535528. 
  4. ^ White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm. 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. PMID 15193453. 
  5. ^ a b "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor". 

Further reading[edit]