Low-density lipoprotein receptor adapter protein 1

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Available structures
PDB Ortholog search: PDBe RCSB
Aliases LDLRAP1, ARH, ARH1, ARH2, FHCB1, FHCB2, low density lipoprotein receptor adaptor protein 1
External IDs MGI: 2140175 HomoloGene: 9219 GeneCards: LDLRAP1
RNA expression pattern
PBB GE LDLRAP1 57082 at fs.png

PBB GE LDLRAP1 221790 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 25.54 – 25.57 Mb Chr 4: 134.74 – 134.77 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Low-density lipoprotein receptor adapter protein 1 is a protein that in humans is encoded by the LDLRAP1 gene.[3]

The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTB) domain. The PTB domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.[3]


LDLRAP1 has been shown to interact with AP2B1[4][5] and LRP2.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: LDLRAP1 low density lipoprotein receptor adaptor protein 1". 
  4. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ He, Guocheng; Gupta Sarita; Yi Ming; Michaely Peter; Hobbs Helen H; Cohen Jonathan C (Nov 2002). "ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2". J. Biol. Chem. United States. 277 (46): 44044–9. doi:10.1074/jbc.M208539200. ISSN 0021-9258. PMID 12221107. 
  6. ^ Nagai, Masaaki; Meerloo Timo; Takeda Tetsuro; Farquhar Marilyn Gist (Dec 2003). "The adaptor protein ARH escorts megalin to and through endosomes". Mol. Biol. Cell. United States. 14 (12): 4984–96. doi:10.1091/mbc.E03-06-0385. ISSN 1059-1524. PMC 284800Freely accessible. PMID 14528014. 

Further reading[edit]