Galectin-2

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LGALS2
Protein LGALS2 PDB 1hlc.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLGALS2, HL14, galectin 2
External IDsMGI: 895068 HomoloGene: 4741 GeneCards: LGALS2
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for LGALS2
Genomic location for LGALS2
Band22q13.1Start37,570,246 bp[1]
End37,582,616 bp[1]
RNA expression pattern
PBB GE LGALS2 208450 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006498

NM_025622

RefSeq (protein)

NP_006489

NP_079898

Location (UCSC)Chr 22: 37.57 – 37.58 MbChr 15: 78.85 – 78.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Galectin-2 is a protein that in humans is encoded by the LGALS2 gene.[5][6][7]

The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100079 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043501 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Gitt MA, Barondes SH (Feb 1991). "Genomic sequence and organization of two members of a human lectin gene family". Biochemistry. 30 (1): 82–9. doi:10.1021/bi00215a013. PMID 1988031.
  6. ^ Sturm A, Lensch M, Andre S, Kaltner H, Wiedenmann B, Rosewicz S, Dignass AU, Gabius HJ (Sep 2004). "Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation". J Immunol. 173 (6): 3825–37. doi:10.4049/jimmunol.173.6.3825. PMID 15356130.
  7. ^ a b "Entrez Gene: LGALS2 lectin, galactoside-binding, soluble, 2".

Further reading[edit]