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Protein LHX2 PDB 2dmq.png
Aliases LHX2, LH2, hLhx2, LIM homeobox 2
External IDs MGI: 96785 HomoloGene: 55848 GeneCards: LHX2
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for LHX2
Genomic location for LHX2
Band 9q33.3 Start 124,001,670 bp[1]
End 124,033,301 bp[1]
RNA expression pattern
PBB GE LHX2 211219 s at fs.png

PBB GE LHX2 206140 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 124 – 124.03 Mb Chr 2: 38.34 – 38.37 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.[5][6][7]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.[7]


LHX2 has been shown to interact with CITED2.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106689 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000247 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (Jul 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–12. PMID 8649822. 
  6. ^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (Apr 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–70. doi:10.1073/pnas.96.5.2165. PMC 26754Freely accessible. PMID 10051612. 
  7. ^ a b "Entrez Gene: LHX2 LIM homeobox 2". 
  8. ^ Glenn, D J; Maurer R A (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. UNITED STATES. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900. 

Further reading[edit]