LHX4

From Wikipedia, the free encyclopedia
Jump to: navigation, search
LHX4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LHX4, CPHD4, LIM homeobox 4
External IDs MGI: 101776 HomoloGene: 56497 GeneCards: LHX4
RNA expression pattern
PBB GE LHX4 gnf1h01135 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033343

NM_010712

RefSeq (protein)

NP_203129

NP_034842.2
NP_034842

Location (UCSC) Chr 1: 180.23 – 180.28 Mb Chr 1: 155.7 – 155.75 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene.[3][4][5]

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Liu Y, Fan M, Yu S, Zhou Y, Wang J, Yuan J, Qiang B (Feb 2002). "cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4". Brain Res. 928 (1–2): 147–155. doi:10.1016/S0006-8993(01)03243-7. PMID 11844481. 
  4. ^ Machinis K, Pantel J, Netchine I, Leger J, Camand OJ, Sobrier ML, Dastot-Le Moal F, Duquesnoy P, Abitbol M, Czernichow P, Amselem S (Oct 2001). "Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4". Am J Hum Genet. 69 (5): 961–968. doi:10.1086/323764. PMC 1274372Freely accessible. PMID 11567216. 
  5. ^ a b "Entrez Gene: LHX4 LIM homeobox 4". 

Further reading[edit]