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Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LILRA2 ; CD85H; ILT1; LIR-7; LIR7
External IDs OMIM604812 HomoloGene68534 GeneCards: LILRA2 Gene
RNA expression pattern
PBB GE LILRA2 207857 at tn.png
PBB GE LILRA2 211100 x at tn.png
PBB GE LILRA2 211101 x at tn.png
More reference expression data
Species Human Mouse
Entrez 11027 n/a
Ensembl ENSG00000239998 n/a
UniProt Q8N149 n/a
RefSeq (mRNA) NM_001130917 n/a
RefSeq (protein) NP_001124389 n/a
Location (UCSC) Chr 19:
55.08 – 55.1 Mb
PubMed search [1] n/a

Leukocyte immunoglobulin-like receptor subfamily A member 2 is a protein that in humans is encoded by the LILRA2 gene.[1][2][3]

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM][3]

See also[edit]


  1. ^ Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. 
  2. ^ Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol 159 (11): 5192–6. PMID 9548455. 
  3. ^ a b "Entrez Gene: LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.