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Leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LILRA3 ; CD85E; HM31; HM43; ILT6; LIR-4; LIR4; e3
External IDs OMIM604818 HomoloGene128752 GeneCards: LILRA3 Gene
RNA expression pattern
PBB GE LILRA3 206881 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11026 n/a
Ensembl ENSG00000170866 n/a
UniProt Q8N6C8 n/a
RefSeq (mRNA) NM_001172654 n/a
RefSeq (protein) NP_001166125 n/a
Location (UCSC) Chr 19:
54.8 – 54.81 Mb
PubMed search [1] n/a

Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the eukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown. however it is highly homologous to other LILR genes,[1] and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.[2][3][4]

Like the closely related LILRA1, LILRA3 binds to both normal and 'unfolded' free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles [5]

See also[edit]


  1. ^ Torkar M, Haude A, Milne S, Beck S, Trowsdale J,Wilson MJ (2000). "Arrangement of the ILT gene cluster: a common null allele of the LT6 gene results from a 6.7-kbp deletion". Eur J Immunol 30: 3655. doi:10.1002/1521-4141(200012)30:12<3655::aid-immu3655>;2-y. PMID 1169408. 
  2. ^ Arm JP, Nwankwo C, Austen KF (Sep 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". J Immunol 159 (5): 2342–9. PMID 9278324. 
  3. ^ Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol 159 (11): 5192–6. PMID 9548455. 
  4. ^ "Entrez Gene: LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3". 
  5. ^ Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL (Mar 2011). "HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding". J Immunol 186 (5): 2990–7. doi:10.4049/jimmunol.1003078. PMID 21270408. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.