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Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Protein LILRB1 PDB 1g0x.png
PDB rendering based on 1g0x.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LILRB1 ; CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7; MIR7
External IDs OMIM604811 HomoloGene88463 GeneCards: LILRB1 Gene
RNA expression pattern
PBB GE LILRB1 211336 x at tn.png
PBB GE LILRB1 207104 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10859 n/a
Ensembl ENSG00000104972 n/a
UniProt Q8NHL6 n/a
RefSeq (mRNA) NM_001081637 n/a
RefSeq (protein) NP_001075106 n/a
Location (UCSC) Chr 19:
54.62 – 54.7 Mb
PubMed search [1] n/a

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.[1][2]


This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

See also[edit]


  1. ^ Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (Aug 1997). "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules". Immunity 7 (2): 273–82. doi:10.1016/S1074-7613(00)80529-4. PMID 9285411. 
  2. ^ Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880. 
  3. ^ "Entrez Gene: LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.