LILRB1

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LILRB1
Protein LILRB1 PDB 1g0x.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases LILRB1, CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB, leukocyte immunoglobulin like receptor B1
External IDs HomoloGene: 88463 GeneCards: LILRB1
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for LILRB1
Genomic location for LILRB1
Band 19q13.42 Start 54,617,158 bp[1]
End 54,637,528 bp[1]
RNA expression pattern
PBB GE LILRB1 207104 x at fs.png

PBB GE LILRB1 211336 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC) Chr 19: 54.62 – 54.64 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.[3][4]

Function[edit]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

See also[edit]

References[edit]

  1. ^ a b c ENSG00000276452, ENSG00000277134, ENSG00000274669, ENSG00000277807 GRCh38: Ensembl release 89: ENSG00000104972, ENSG00000276452, ENSG00000277134, ENSG00000274669, ENSG00000277807 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (Aug 1997). "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules". Immunity. 7 (2): 273–82. PMID 9285411. doi:10.1016/S1074-7613(00)80529-4. 
  4. ^ Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine. 186 (11): 1809–18. PMC 2199153Freely accessible. PMID 9382880. doi:10.1084/jem.186.11.1809. 
  5. ^ "Entrez Gene: LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.