Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3gene.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
^Arm JP, Nwankwo C, Austen KF (Sep 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". J Immunol. 159 (5): 2342–9. PMID9278324.
Sloane DE, Tedla N, Awoniyi M, et al. (2004). "Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.". Blood. 104 (9): 2832–9. PMID15242876. doi:10.1182/blood-2004-01-0268.
Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster.". Immunogenetics. 51 (8-9): 703–13. PMID10941842. doi:10.1007/s002510000187.
Borges L, Hsu ML, Fanger N, et al. (1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.". J. Immunol. 159 (11): 5192–6. PMID9548455.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. PMID9373149. doi:10.1016/S0378-1119(97)00411-3.
Samaridis J, Colonna M (1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.". Eur. J. Immunol. 27 (3): 660–5. PMID9079806. doi:10.1002/eji.1830270313.