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Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
Symbols LILRB3 ; CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3; LIR3; PIRB
External IDs OMIM604820 MGI1195971 HomoloGene134028 GeneCards: LILRB3 Gene
RNA expression pattern
PBB GE LILRB3 208594 x at tn.png
PBB GE LILRB3 210784 x at tn.png
PBB GE LILRB3 210225 x at tn.png
More reference expression data
Species Human Mouse
Entrez 11025 18722
Ensembl ENSG00000204577 ENSMUSG00000074417
UniProt Q6PI73 n/a
RefSeq (mRNA) NM_001081450 NM_011087
RefSeq (protein) NP_001074919 NP_035217
Location (UCSC) Chr 19:
54.22 – 54.22 Mb
Chr 7:
3.84 – 3.85 Mb
PubMed search [1] [2]

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.[1][2][3]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

See also[edit]


  1. ^ Arm JP, Nwankwo C, Austen KF (Sep 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". J Immunol 159 (5): 2342–9. PMID 9278324. 
  2. ^ Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". J Exp Med 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880. 
  3. ^ a b "Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.