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Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LILRB4 ; CD85K; ILT-3; ILT3; LIR-5; LIR5
External IDs OMIM604821 HomoloGene86756 GeneCards: LILRB4 Gene
RNA expression pattern
PBB GE LILRB4 210152 at tn.png
More reference expression data
Species Human Mouse
Entrez 11006 14727
Ensembl ENSG00000186818 ENSMUSG00000089672
UniProt Q8NHJ6 Q61450
RefSeq (mRNA) NM_001081438 NM_001291892
RefSeq (protein) NP_001265355 NP_001278821
Location (UCSC) Chr 19:
54.64 – 54.67 Mb
Chr 10:
51.48 – 51.49 Mb
PubMed search [1] [2]

Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene.[1][2][3]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]


LILRB4 has been shown to interact with PTPN6.[4]

See also[edit]


  1. ^ Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (Jun 1997). "A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing". J Exp Med 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699. 
  2. ^ Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. 
  3. ^ a b "Entrez Gene: LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4". 
  4. ^ Wang, L L; Blasioli J; Plas D R; Thomas M L; Yokoyama W M (Feb 1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". J. Immunol. (UNITED STATES) 162 (3): 1318–23. ISSN 0022-1767. PMID 9973385. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.