LMO1

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LMO1
Identifiers
Aliases LMO1, RBTN1, RHOM1, TTG1, LIM domain only 1
External IDs MGI: 102812 HomoloGene: 48101 GeneCards: LMO1
Genetically Related Diseases
alcohol abuse, neuroblastoma[1]
RNA expression pattern
PBB GE LMO1 206718 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270428
NM_002315

NM_001302205
NM_001302206
NM_057173

RefSeq (protein)

NP_001257357
NP_002306

Location (UCSC) Chr 11: 8.22 – 8.27 Mb Chr 7: 109.14 – 109.18 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.[4][5][6]

LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.[6]

Interactions[edit]

LMO1 has been shown to interact with GATA3[7][8] and TAL1.[9][10]

References[edit]

  1. ^ "Diseases that are genetically associated with LMO1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proc Natl Acad Sci U S A. 88 (10): 4367–71. doi:10.1073/pnas.88.10.4367. PMC 51660Freely accessible. PMID 2034676. 
  5. ^ McGuire EA, Davis AR, Korsmeyer SJ (March 1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells". Blood. 77 (3): 599–606. PMID 1703797. 
  6. ^ a b "Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)". 
  7. ^ Ono, Y; Fukuhara N; Yoshie O (December 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Mol. Cell. Biol. UNITED STATES. 18 (12): 6939–50. ISSN 0270-7306. PMC 109277Freely accessible. PMID 9819382. 
  8. ^ Ono, Y; Fukuhara N; Yoshie O (February 1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL". J. Biol. Chem. UNITED STATES. 272 (7): 4576–81. doi:10.1074/jbc.272.7.4576. ISSN 0021-9258. PMID 9020185. 
  9. ^ Valge-Archer, V E; Osada H; Warren A J; Forster A; Li J; Baer R; Rabbitts T H (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. ISSN 0027-8424. PMC 44657Freely accessible. PMID 8078932. 
  10. ^ Wadman, I; Li J; Bash R O; Forster A; Osada H; Rabbitts T H; Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. ENGLAND. 13 (20): 4831–9. ISSN 0261-4189. PMC 395422Freely accessible. PMID 7957052. 

Further reading[edit]