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Lemur tyrosine kinase 2
Symbols LMTK2 ; AATYK2; BREK; KPI-2; KPI2; LMR2; PPP1R100; cprk
External IDs OMIM610989 MGI3036247 HomoloGene8948 IUPHAR: 2056 GeneCards: LMTK2 Gene
EC number
RNA expression pattern
PBB GE LMTK2 206223 at tn.png
More reference expression data
Species Human Mouse
Entrez 22853 231876
Ensembl ENSG00000164715 ENSMUSG00000038970
UniProt Q8IWU2 Q3TYD6
RefSeq (mRNA) NM_014916 NM_001081109
RefSeq (protein) NP_055731 NP_001074578
Location (UCSC) Chr 7:
97.74 – 97.84 Mb
Chr 5:
144.1 – 144.19 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase LMTK2 also known as Lemur tyrosine kinase 2 (LMTK2) is an enzyme that in humans is encoded by the LMTK2 gene.[1][2]


The LMTK2 enzyme belongs to both the protein kinase and the tyrosine kinase families. It contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein is involved in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.[2]


LMTK2 has been shown to interact with PPP1CA,[3] Cyclin-dependent kinase 5[4] and PPP1R2.[3]


  1. ^ Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T (Mar 2004). "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling". Genes Cells 9 (3): 219–32. doi:10.1111/j.1356-9597.2004.00714.x. PMID 15005709. 
  2. ^ a b "Entrez Gene: LMTK2 lemur tyrosine kinase 2". 
  3. ^ a b Wang, Hong; Brautigan David L (Dec 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. Biol. Chem. (United States) 277 (51): 49605–12. doi:10.1074/jbc.M209335200. ISSN 0021-9258. PMID 12393858. 
  4. ^ Kesavapany, Sashi; Lau Kwok-Fai; Ackerley Steven; Banner Steven J; Shemilt Stephen J A; Cooper Jonathan D; Leigh P Nigel; Shaw Christopher E; McLoughlin Declan M; Miller Christopher C J (Jun 2003). "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase". J. Neurosci. (United States) 23 (12): 4975–83. PMID 12832520. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.