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Adhesion G protein-coupled receptor L2
Symbols ADGRL2 ; CIRL2; CL2; LEC1; LPHH1; LPHN2
External IDs OMIM607018 MGI2139714 HomoloGene22712 IUPHAR: GeneCards: ADGRL2 Gene
RNA expression pattern
PBB GE LPHN2 206953 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23266 99633
Ensembl ENSG00000117114 ENSMUSG00000028184
UniProt O95490 Q8JZZ7
RefSeq (mRNA) NM_001297704 NM_001081298
RefSeq (protein) NP_001284633 NP_001074767
Location (UCSC) Chr 1:
81.31 – 81.99 Mb
Chr 3:
148.82 – 148.99 Mb
PubMed search [1] [2]

Latrophilin-2 is a protein that in humans is encoded by the ADGRL2 gene.[1][2]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.[2]

See also[edit]


  1. ^ White GR, Varley JM, Heighway J (Jul 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochim Biophys Acta 1491 (1-3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572. 
  2. ^ a b "Entrez Gene: LPHN2 latrophilin 2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.