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LRN may refer to:

  • Laboratory Response Network, a collaborative effort of the U.S. Centers for Disease Control and Prevention and the Association of Public Health Laboratories
  • Laparoscopic radical nephrectomy, a medical procedure
  • Lateral reticular nucleus, a nucleus of the medulla oblongata involved with co-ordinating baroreceptor signals to control arterial blood pressure
  • Legislative route number, a designation for a highway defined by laws passed in a state legislature
  • Location Routing Number, a ten digit phone number used to route phone calls between two telephone exchanges
  • LORAN, a terrestrial radio navigation system originally known as LRN for Loomis Radio Navigation
  • LRN (company), an ethics compliance and education company
  • Luminous red nova, a stellar explosion thought to be caused by the merger of two stars