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Low density lipoprotein receptor-related protein 1B
External IDs OMIM608766 MGI2151136 HomoloGene56810 GeneCards: LRP1B Gene
RNA expression pattern
PBB GE LRP1B 219643 at tn.png
More reference expression data
Species Human Mouse
Entrez 53353 94217
Ensembl ENSG00000168702 ENSMUSG00000049252
UniProt Q9NZR2 Q9JI18
RefSeq (mRNA) NM_018557 NM_053011
RefSeq (protein) NP_061027 NP_443737
Location (UCSC) Chr 2:
140.23 – 142.13 Mb
Chr 2:
40.6 – 42.65 Mb
PubMed search [1] [2]

Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.[1][2]


LRP1B belongs to the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands.[3]


  1. ^ Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA (May 2000). "LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines". Cancer Res 60 (7): 1961–7. PMID 10766186. 
  2. ^ "Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors)". 
  3. ^ Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G (August 2001). "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein". J. Biol. Chem. 276 (31): 28889–96. doi:10.1074/jbc.M102727200. PMID 11384978. 

Further reading[edit]

  • Liu CX, Musco S, Lisitsina NM et al. (2001). "Genomic organization of a new candidate tumor suppressor gene, LRP1B". Genomics 69 (2): 271–4. doi:10.1006/geno.2000.6331. PMID 11031110. 
  • Langbein S, Szakacs O, Wilhelm M et al. (2002). "Alteration of the LRP1B gene region is associated with high grade of urothelial cancer". Lab. Invest. 82 (5): 639–43. doi:10.1038/labinvest.3780458. PMID 12004004. 
  • Li Y, Knisely JM, Lu W et al. (2003). "Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration". J. Biol. Chem. 277 (44): 42366–71. doi:10.1074/jbc.M207705200. PMID 12194987. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Cam JA, Zerbinatti CV, Knisely JM et al. (2004). "The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production". J. Biol. Chem. 279 (28): 29639–46. doi:10.1074/jbc.M313893200. PMID 15126508. 
  • Tanaga K, Bujo H, Zhu Y et al. (2005). "LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors". Arterioscler. Thromb. Vasc. Biol. 24 (8): 1422–8. doi:10.1161/01.ATV.0000133607.80554.09. PMID 15166012. 
  • Sonoda I, Imoto I, Inoue J et al. (2004). "Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma". Cancer Res. 64 (11): 3741–7. doi:10.1158/0008-5472.CAN-04-0172. PMID 15172977. 
  • Li Y, Lu W, Bu G (2005). "Striking differences of LDL receptor-related protein 1B expression in mouse and human". Biochem. Biophys. Res. Commun. 333 (3): 868–73. doi:10.1016/j.bbrc.2005.05.170. PMID 15963947. 
  • Pastrana DV, Hanson AJ, Knisely J et al. (2006). "LRP 1 B functions as a receptor for Pseudomonas exotoxin". Biochim. Biophys. Acta 1741 (3): 234–9. doi:10.1016/j.bbadis.2005.06.007. PMID 16095885. 
  • Nakagawa T, Pimkhaokham A, Suzuki E et al. (2006). "Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma". Cancer Sci. 97 (10): 1070–4. doi:10.1111/j.1349-7006.2006.00283.x. PMID 16918994. 
  • Liu CX, Ranganathan S, Robinson S, Strickland DK (2007). "gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells". J. Biol. Chem. 282 (10): 7504–11. doi:10.1074/jbc.M608088200. PMID 17227771.