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LRU may refer to:
- Latvian Russian Union, an ethnic minority, left-wing political party in Latvia
- Las Cruces International Airport's IATA code
- Least Recently Used, a cache replacement algorithm
- Lenoir–Rhyne University
- Liberties and Responsibilities of Universities, a French law voted in 2007
- Line-replaceable unit, a modular component of an airplane or other manufactured device
- London Reform Union
| disambiguation page lists articles associated with the title LRU.
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