Lysergic acid diethylamide
|Systematic (IUPAC) name|
|Oral, sublingual, intravenous, ocular, intramuscular|
|Biological half-life||3–5 hours|
|CAS Registry Number|
|Synonyms||Acid, LSD, lysergide|
|Molecular mass||323.44 g·mol−1|
|Melting point||80 to 85 °C (176 to 185 °F)|
|(what is this?)|
Lysergic acid diethylamide (/daɪ eθəl ˈæmaɪd/ or /æmɪd/ or /eɪmaɪd/), abbreviated LSD or LSD-25, also known as lysergide (INN) and colloquially as acid, is a psychedelic drug of the ergoline family, well known for its psychological effects - which can include altered thinking processes, closed- and open-eye visuals, synesthesia, an altered sense of time, and spiritual experiences - as well as for its key role in 1960s counterculture. It is used mainly as an entheogen and recreational drug. LSD is non-addictive. However, acute adverse psychiatric reactions such as anxiety, paranoia, and delusions are possible.
LSD was first synthesized by Albert Hofmann in 1938 from ergotamine, a chemical derived by Arthur Stoll from ergot, a grain fungus that typically grows on rye. The short form "LSD" comes from its early code name LSD-25, which is an abbreviation for the German "Lysergsäure-diethylamid" followed by a sequential number. LSD is sensitive to oxygen, ultraviolet light, and chlorine, especially in solution, though its potency may last for years if it is stored away from light and moisture at low temperature. In pure form it is a colorless, odorless, tasteless solid. LSD is typically either swallowed (oral) or held under the tongue (sublingual), usually on a substrate such as absorbent blotter paper, a sugar cube, or gelatin. In its liquid form, it can also be administered by intramuscular or intravenous injection. Interestingly, unlike most other classes of illicit drugs and other groups of psychedelic drugs such as tryptamines and phenethylamines, when LSD is administered via intravenous injection the onset is not immediate, instead taking approximately 30 minutes before the effects are realized. LSD is very potent, with 20–30 µg (micrograms) being the threshold dose.
Hofmann discovered the psychedelic properties of LSD in 1943. It was introduced commercially in 1947 by Sandoz Laboratories under the trade-name Delysid as a drug with various psychiatric uses. In the 1950s, officials at the U.S. Central Intelligence Agency (CIA) thought the drug might be applicable to mind control and chemical warfare; the agency's MKULTRA research program propagated the drug among young servicemen and students. The subsequent recreational use of the drug by youth culture in the Western world during the 1960s led to a political firestorm that resulted in its prohibition.
- 1 Effects
- 2 Uses
- 3 Adverse effects
- 4 Overdose
- 5 Pharmacology
- 6 Physical and chemical properties
- 7 History
- 8 Society and culture
- 9 Research
- 10 See also
- 11 References
- 12 Further reading
- 13 External links
LSD can cause pupil dilation, reduced appetite, and wakefulness. Other physical reactions to LSD are highly variable and nonspecific, some of which may be secondary to the psychological effects of LSD. Among the reported symptoms are numbness, weakness, nausea, hypothermia or hyperthermia, elevated blood sugar, goose bumps, heart rate increase, jaw clenching, perspiration, saliva production, mucus production, sleeplessness, hyperreflexia, and tremors.[medical citation needed]
LSD's psychological effects (colloquially called a "trip") vary greatly between persons and places. If the user is in a hostile or otherwise unsettling environment, or is not mentally prepared for the powerful distortions in perception and thought that the drug causes, effects are more likely to be unpleasant than if he or she is in a comfortable environment and has a relaxed, balanced and open mindset.[medical citation needed]
An LSD trip can have long-term psychological or emotional effects; some users[who?] report the LSD experience as causing significant long term changes in their personality and life perspective. Widely different effects emerge based on what Timothy Leary called set and setting; the "set" being the general mindset of the user, and the "setting" being the physical and social environment in which the drug's effects are experienced. Some psychological effects may include a sense that one's thoughts are spiraling into themselves and a loss of a sense of identity or the ego (known as "ego death").[medical citation needed] Many users experience a dissolution between themselves and the "outside world". This unitive quality may play a role in the spiritual and religious aspects of LSD. The drug sometimes leads to disintegration or restructuring of the user's historical personality and creates a mental state that some users[weasel words] report allows them to have more choice regarding the nature of their own personality.[medical citation needed]
Some sensory effects may include an experience of radiant colors, objects and surfaces appearing to ripple or "breathe", colored patterns behind the closed eyelids (eidetic imagery), an altered sense of time (time seems to be stretching, repeating itself, changing speed or stopping), crawling geometric patterns overlaying walls and other objects, and morphing objects. Some users, including Albert Hofmann, report a strong metallic taste for the duration of the effects.
LSD causes an animated sensory experience of senses, emotions, memories, time, and awareness for 6 to 14 hours, depending on dosage and tolerance. Generally beginning within 30 to 90 minutes after ingestion, the user may experience anything from subtle changes in perception to overwhelming cognitive shifts. Changes in auditory and visual perception are typical. Visual effects include the illusion of movement of static surfaces ("walls breathing"), after image-like trails of moving objects ("tracers"), the appearance of moving colored geometric patterns (especially with closed eyes), an intensification of colors and brightness ("sparkling"), new textures on objects, blurred vision, and shape suggestibility. Users commonly report[weasel words] that the inanimate world appears to animate in an inexplicable way; for instance, objects that are static in three dimensions can seem to be moving relative to one or more additional spatial dimensions. Many of the basic visual effects resemble the phosphenes seen after applying pressure to the eye and have also been studied under the name "form constants". The auditory effects of LSD may include echo-like distortions of sounds, changes in ability to discern concurrent auditory stimuli, and a general intensification of the experience of music. Higher doses often cause intense and fundamental distortions of sensory perception such as synaesthesia, the experience of additional spatial or temporal dimensions, and temporary dissociation.[medical citation needed]
LSD currently has no recognized medical use.
Recreational and spiritual
Despite its mostly illegal status worldwide, LSD is commonly used as a recreational drug for its psychedelic effects.
LSD is considered an entheogen because it can catalyze intense spiritual experiences, during which users may feel they have come into contact with a greater spiritual or cosmic order. Users claim to experience lucid sensations where they have "out of body" experiences. In 1966, Timothy Leary established the League for Spiritual Discovery with LSD as its sacrament. Stanislav Grof has written that religious and mystical experiences observed during LSD sessions appear to be phenomenologically indistinguishable from similar descriptions in the sacred scriptures of the great religions of the world and the secret mystical texts of ancient civilizations.
Suicide and acts of violence have been associated with LSD use. Long-term effects include "flashbacks" and a syndrome of long-term perceptual changes that are experienced as distressing LSD can temporarily impair the ability to fully understand common dangers and therefore users may be more susceptible to personal injury and accidents. LSD may also cause temporary confusion, difficulty with abstract thinking, or signs of impaired memory and attention span.
LSD may trigger panic attacks or feelings of extreme anxiety, colloquially referred to as a "bad trip". There is evidence that people with severe mental illnesses like schizophrenia have a higher likelihood of experiencing adverse effects from taking LSD (see psychosis for further details).[unreliable medical source] No real prolonged effects have been proven, although PTSD has been reported after some intensely distressful LSD experiences.[medical citation needed]
While publicly available documents indicate that the CIA and Department of Defense have discontinued research into the use of LSD as a means of mind control, research from the 1960s suggests there exists evidence that both mentally ill and healthy people are more suggestible while under its influence.[non-primary source needed]
Flashbacks and HPPD
"Flashbacks" are a reported psychological phenomenon in which an individual experiences an episode of some of LSD's subjective effects long after the drug has worn off, usually in the days after typical doses.[medical citation needed] Several studies have tried to determine how likely a user of LSD, not suffering from known psychiatric conditions, is to experience flashbacks. The larger studies include Blumenfeld's in 1971[non-primary source needed] and Naditch and Fenwick's in 1977,[non-primary source needed] which arrived at figures of 20% and 28%, respectively.[unreliable medical source]
Hallucinogen Persisting Perception Disorder (HPPD) describes a post-LSD exposure syndrome which LSD-like visual changes are not temporary and brief, as they are in flashbacks, but instead are persistent, and cause clinically significant impairment or distress. The syndrome is a DSM-IV diagnosis. Several scientific journal articles have described the disorder. HPPD differs from flashbacks in that it is persistent and apparently entirely visual (although mood and anxiety disorders are sometimes diagnosed in the same individuals). A recent review suggests that HPPD (as defined in the DSM-IV) is uncommon and affects a distinctly vulnerable subpopulation of users.
Early pharmacological testing by Sandoz in laboratory animals showed that LSD can stimulate uterine contractions, with efficacy comparable to ergobasine, the active uterotonic component of the ergot fungus.[medical citation needed]
The mutagenic potential of LSD is unclear. Overall, the evidence seems to point to limited or no effect at commonly used doses.
Addiction and tolerance
LSD is not considered addictive by the medical community and experimental evidence has demonstrated that positive reinforcement, which is a necessary condition for addiction, does not arise when it is used by humans or other animals. Tolerance to LSD-25 builds up over consistent use and cross-tolerance has been demonstrated between LSD, mescaline and psilocybin. This tolerance diminishes a few days after cessation of use and is probably caused by downregulation of 5-HT2A receptors in the brain.
Reassurance in a calm, safe environment is beneficial. Agitation can be safely addressed with benzodiazepines such as lorazepam or diazepam. Neuroleptics such as haloperidol should be avoided for they may have adverse effects. LSD is rapidly absorbed, so activated charcoal and emptying of the stomach will be of little benefit, unless done within 30-60 minutes of ingesting vast amounts of LSD. Sedation or physical restraint is rarely required, and excessive restraint may cause complications such as hyperthermia (over-heating) or rhabdomyolysis.
Massive doses require supportive care, which may include endotracheal intubation or respiratory support. Overdose has been recorded at 1,000 to 7,000μg per 100ml & 2.1 to 26ng per ml in serum concentrations of the tartrate salt form. High blood pressure, tachycardia (rapid heart-beat) and hyperthermia, if present, should be treated symptomatically. Treat low blood pressure initially with fluids and then with pressors if necessary. Intravenous administration of anticoagulants, vasodilators, and sympatholytics may be useful with massive doses.
LSD's effects normally last from 6–12 hours depending on dosage, tolerance, body weight and age. The Sandoz prospectus for "Delysid" warned: "intermittent disturbances of affect may occasionally persist for several days." Contrary to early reports and common belief, LSD effects do not last longer than the amount of time significant levels of the drug are present in the blood. Aghajanian and Bing (1964) found LSD had an elimination half-life of only 175 minutes. However, using more accurate techniques, Papac and Foltz (1990) reported that 1 µg/kg oral LSD given to a single male volunteer had an apparent plasma half-life of 5.1 hours, with a peak plasma concentration of 5 ng/mL at 3 hours post-dose.
LSD affects a large number of the G protein-coupled receptors, including all dopamine receptor subtypes, and all adrenoreceptor subtypes, as well as many others. Most serotonergic psychedelics are not significantly dopaminergic, and LSD is therefore rather unique in this regard. LSD's agonism of D2 receptors contributes to its psychoactive effects. LSD binds to most serotonin receptor subtypes except for 5-HT3 and 5-HT4. However, most of these receptors are affected at too low affinity to be sufficiently activated by the brain concentration of approximately 10–20 nM. In humans, recreational doses of LSD can affect 5-HT1A (Ki=1.1nM), 5-HT2A (Ki=2.9nM), 5-HT2B (Ki=4.9nM), 5-HT2C (Ki=23nM), 5-HT5A (Ki=9nM [in cloned rat tissues]), and 5-HT6 receptors (Ki=2.3nM). 5-HT5B receptors, which are not present in humans, also have a high affinity for LSD. The psychedelic effects of LSD are attributed to cross-activation of 5-HT2A receptor heteromers. Many but not all 5-HT2A agonists are psychedelics and 5-HT2A antagonists block the psychedelic activity of LSD. LSD exhibits functional selectivity at the 5-HT2A and 5HT2C receptors in that it activates the signal transduction enzyme phospholipase A2 instead of activating the enzyme phospholipase C as the endogenous ligand serotonin does. Exactly how LSD produces its effects is unknown, but it is thought that it works by increasing glutamate release in the cerebral cortex and therefore excitation in this area, specifically in layers IV and V. LSD, like many other drugs, has been shown to activate DARPP-32-related pathways.
Physical and chemical properties
LSD is a chiral compound with two stereocenters at the carbon atoms C-5 and C-8, so that theoretically four different optical isomers of LSD could exist. LSD, also called (+)-D-LSD, has the absolute configuration (5R,8R). The C-5 isomers of lysergamides do not exist in nature and are not formed during the synthesis from D-lysergic acid. Retrosynthetically, the C-5 stereocenter could be analysed as having the same configuration of the alpha carbon of the naturally occurring amino acid L-tryptophan, the precursor to all biosynthetic ergoline compounds.
However, LSD and iso-LSD, the two C-8 isomers, rapidly interconvert in the presence of bases, as the alpha proton is acidic and can be deprotonated and reprotonated. Non-psychoactive iso-LSD which has formed during the synthesis can be separated by chromatography and can be isomerized to LSD.
LSD is an ergoline derivative. It is commonly synthesised by reacting diethylamine with an activated form of lysergic acid. Activating reagents include phosphoryl chloride and peptide coupling reagents. Lysergic acid is made by alkaline hydrolysis of lysergamides like ergotamine, a substance usually derived from the ergot fungus on agar plate, or theoretically possible, but impractical and uncommon from ergine (lysergic acid amide, LSA) extracted from morning glory seeds. Lysergic acid can also be produced synthetically, eliminating the need for ergotamines.
A single dose of LSD may be between 40 and 500 micrograms—an amount roughly equal to one-tenth the mass of a grain of sand. Threshold effects can be felt with as little as 25 micrograms of LSD. Dosages of LSD are measured in micrograms (µg), or millionths of a gram. By comparison, dosages of most drugs, both recreational and medicinal, are measured in milligrams (mg), or thousandths of a gram. For example, an active dose of mescaline, roughly 0.2 to 0.5 g, has effects comparable to 100 µg or less of LSD.
In the mid-1960s, the most important black market LSD manufacturer (Owsley Stanley) distributed acid at a standard concentration of 270 µg, while street samples of the 1970s contained 30 to 300 µg. By the 1980s, the amount had reduced to between 100 and 125 µg, dropping more in the 1990s to the 20–80 µg range, and even more in the 2000s (decade). 
Reactivity and degradation
LSD has two labile protons at the tertiary stereogenic C5 and C8 positions, rendering these centres prone to epimerisation. The C8 proton is more labile due to the electron-withdrawing carboxamide attachment, but removal of the chiral proton at the C5 position (which was once also an alpha proton of the parent molecule tryptophan) is assisted by the inductively withdrawing nitrogen and pi electron delocalisation with the indole ring.
LSD also has enamine-type reactivity because of the electron-donating effects of the indole ring. Because of this, chlorine destroys LSD molecules on contact; even though chlorinated tap water contains only a slight amount of chlorine, the small quantity of compound typical to an LSD solution will likely be eliminated when dissolved in tap water. The double bond between the 8-position and the aromatic ring, being conjugated with the indole ring, is susceptible to nucleophilic attacks by water or alcohol, especially in the presence of light. LSD often converts to "lumi-LSD", which is inactive in human beings.
A controlled study was undertaken to determine the stability of LSD in pooled urine samples. The concentrations of LSD in urine samples were followed over time at various temperatures, in different types of storage containers, at various exposures to different wavelengths of light, and at varying pH values. These studies demonstrated no significant loss in LSD concentration at 25 °C for up to four weeks. After four weeks of incubation, a 30% loss in LSD concentration at 37 °C and up to a 40% at 45 °C were observed. Urine fortified with LSD and stored in amber glass or nontransparent polyethylene containers showed no change in concentration under any light conditions. Stability of LSD in transparent containers under light was dependent on the distance between the light source and the samples, the wavelength of light, exposure time, and the intensity of light. After prolonged exposure to heat in alkaline pH conditions, 10 to 15% of the parent LSD epimerized to iso-LSD. Under acidic conditions, less than 5% of the LSD was converted to iso-LSD. It was also demonstrated that trace amounts of metal ions in buffer or urine could catalyze the decomposition of LSD and that this process can be avoided by the addition of EDTA.
Detection in body fluids
LSD may be quantified in urine as part of a drug abuse testing program, in plasma or serum to confirm a diagnosis of poisoning in hospitalized victims or in whole blood to assist in a forensic investigation of a traffic or other criminal violation or a case of sudden death. Both the parent drug and its major metabolite are unstable in biofluids when exposed to light, heat or alkaline conditions and therefore specimens are protected from light, stored at the lowest possible temperature and analyzed quickly to minimize losses.
LSD was first synthesized on November 16, 1938 by Swiss chemist Albert Hofmann at the Sandoz Laboratories in Basel, Switzerland as part of a large research program searching for medically useful ergot alkaloid derivatives. LSD's psychedelic properties were discovered 5 years later when Hofmann himself accidentally ingested an unknown quantity of the chemical. The first intentional ingestion of LSD occurred on April 19, 1943, when Hofmann ingested 250 µg of LSD. He said this would be a threshold dose based on the dosages of other ergot alkaloids. Hofmann found the effects to be much stronger than he anticipated. Sandoz Laboratories introduced LSD as a psychiatric drug in 1947.
Beginning in the 1950s, the US Central Intelligence Agency began a research program code named Project MKULTRA. Experiments included administering LSD to CIA employees, military personnel, doctors, other government agents, prostitutes, mentally ill patients, and members of the general public in order to study their reactions, usually without the subjects' knowledge. The project was revealed in the US congressional Rockefeller Commission report in 1975.
In 1963, the Sandoz patents expired on LSD. Several figures, including Aldous Huxley, Timothy Leary, and Al Hubbard, began to advocate the consumption of LSD. LSD became central to the counterculture of the 1960s. On October 24, 1968, possession of LSD was made illegal in the United States. The last FDA approved study of LSD in patients ended in 1980, while a study in healthy volunteers was made in the late 1980s. Legally approved and regulated psychiatric use of LSD continued in Switzerland until 1993.
Society and culture
||The examples and perspective in this section deal primarily with the English-speaking world and do not represent a worldwide view of the subject. (January 2013)|
The United Nations Convention on Psychotropic Substances (adopted in 1971) requires its parties to prohibit LSD. Hence, it is illegal in all parties to the convention, which includes the United States, Australia, New Zealand, and most of Europe. However, enforcement of extant laws varies from country to country. Medical and scientific research with LSD in humans is permitted under the 1971 UN Convention.
In Canada, LSD is a controlled substance under Schedule III of the Controlled Drugs and Substances Act. Every person who seeks to obtain the substance, without disclosing authorization to obtain such substances 30 days before obtaining another prescription from a practitioner, is guilty of an indictable offense and liable to imprisonment for a term not exceeding 3 years. Possession for purpose of trafficking is an indictable offense punishable by imprisonment for 10 years.
In the United Kingdom, LSD is a Schedule 1 Class 'A' drug. This means it has no recognised legitimate uses and possession of the drug without a license is punishable with 7 years' imprisonment and/or an unlimited fine, and trafficking is punishable with life imprisonment and an unlimited fine (see main article on drug punishments Misuse of Drugs Act 1971).
In 2000, after consultation with members of the Royal College of Psychiatrists' Faculty of Substance Misuse, the UK Police Foundation issued the Runciman Report which recommended "the transfer of LSD from Class A to Class B".
In November 2009, the UK Transform Drug Policy Foundation released in the House of Commons a guidebook to the legal regulation of drugs, After the War on Drugs: Blueprint for Regulation, which details options for regulated distribution and sale of LSD and other psychedelics.
LSD is Schedule I in the United States, according to the Controlled Substances Act of 1970. This means LSD is illegal to manufacture, buy, possess, process, or distribute without a DEA license. By classifying LSD as a Schedule I substance, the Drug Enforcement Administration holds that LSD meets the following three criteria: it is deemed to have a high potential for abuse; it has no legitimate medical use in treatment; and there is a lack of accepted safety for its use under medical supervision. There are no documented deaths from chemical toxicity; most LSD deaths are a result of behavioral toxicity.
There can also be substantial discrepancies between the amount of chemical LSD that one possesses and the amount of possession with which one can be charged in the U.S. This is because LSD is almost always present in a medium (e.g. blotter or neutral liquid), and the amount that can be considered with respect to sentencing is the total mass of the drug and its medium. This discrepancy was the subject of 1995 United States Supreme Court case, Neal v. U.S.
Lysergic acid and lysergic acid amide, LSD precursors, are both classified in Schedule III of the Controlled Substances Act. Ergotamine tartrate, a precursor to lysergic acid, is regulated under the Chemical Diversion and Trafficking Act.
An active dose of LSD is very minute, allowing a large number of doses to be synthesized from a comparatively small amount of raw material. Twenty five kilograms of precursor ergotamine tartrate can produce 5–6 kg of pure crystalline LSD; this corresponds to 100 million doses. Because the masses involved are so small, concealing and transporting illicit LSD is much easier than smuggling other illegal drugs like cocaine or cannabis.
Manufacturing LSD requires laboratory equipment and experience in the field of organic chemistry. It takes two to three days to produce 30 to 100 grams of pure compound. It is believed that LSD is not usually produced in large quantities, but rather in a series of small batches. This technique minimizes the loss of precursor chemicals in case a step does not work as expected.[dead link]
LSD is produced in crystalline form and then mixed with excipients or redissolved for production in ingestible forms. Liquid solution is either distributed in small vials or, more commonly, sprayed onto or soaked into a distribution medium. Historically, LSD solutions were first sold on sugar cubes, but practical considerations forced a change to tablet form. Appearing in 1968 as an orange tablet measuring about 6 mm across, "Orange Sunshine" acid was the first largely available form of LSD after its possession was made illegal. Tim Scully, a prominent chemist, made some of these tablets, but said that most "Sunshine" in the USA came by way of Ronald Stark, who imported approximately thirty-five million doses from Europe.
Over a period of time, tablet dimensions, weight, shape and concentration of LSD evolved from large (4.5–8.1 mm diameter), heavyweight (≥150 mg), round, high concentration (90–350 µg/tab) dosage units to small (2.0–3.5 mm diameter) lightweight (as low as 4.7 mg/tab), variously shaped, lower concentration (12–85 µg/tab, average range 30–40 µg/tab) dosage units. LSD tablet shapes have included cylinders, cones, stars, spacecraft, and heart shapes. The smallest tablets became known as "Microdots".
After tablets came "computer acid" or "blotter paper LSD", typically made by dipping a preprinted sheet of blotting paper into an LSD/water/alcohol solution. More than 200 types of LSD tablets have been encountered since 1969 and more than 350 blotter paper designs have been observed since 1975. About the same time as blotter paper LSD came "Windowpane" (AKA "Clearlight"), which contained LSD inside a thin gelatin square a quarter of an inch (6 mm) across. LSD has been sold under a wide variety of often short-lived and regionally restricted street names including Acid, Trips, Uncle Sid, Blotter, Lucy, Alice and doses, as well as names that reflect the designs on the sheets of blotter paper. Authorities have encountered the drug in other forms—including powder or crystal, and capsule.
LSD manufacturers and traffickers in the United States can be categorized into two groups: A few large-scale producers, and an equally limited number of small, clandestine chemists, consisting of independent producers who, operating on a comparatively limited scale, can be found throughout the country. As a group, independent producers are of less concern to the Drug Enforcement Administration than the larger groups, as their product reaches only local markets.
Since 2005, law enforcement in the United States and elsewhere has seized several chemicals and combinations of chemicals in blotter paper which were sold as LSD mimics, including DOB, a mixture of DOC and DOI, 25I-NBOMe, and a mixture of DOC and DOB. Street users of LSD are often under the impression that blotter paper which is actively hallucinogenic can only be LSD because that is the only chemical with low enough doses to fit on a small square of blotter paper. While it is true that LSD requires lower doses than most other hallucinogens, blotter paper is capable of absorbing a much larger amount of material. The DEA performed a chromatographic analysis of blotter paper containing 2C-C which showed that the paper contained a much greater concentration of the active chemical than typical LSD doses, although the exact quantity was not determined. Blotter LSD mimics can have relatively small dose squares; a sample of blotter paper containing DOC seized by Concord, California police had dose markings approximately 6 mm apart.
Currently, a number of organizations—including the Beckley Foundation, MAPS, Heffter Research Institute and the Albert Hofmann Foundation—exist to fund, encourage and coordinate research into the medicinal and spiritual uses of LSD and related psychedelics. New clinical LSD experiments in humans started in 2009 for the first time in 35 years.
In 2001 the United States Drug Enforcement Administration stated that LSD "produces no aphrodisiac effects, does not increase creativity, has no lasting positive effect in treating alcoholics or criminals, does not produce a 'model psychosis', and does not generate immediate personality change." More recently experimental uses of LSD have included the treatment of alcoholism and pain and cluster headache relief. It has also been used for spiritual purposes, and for its putative effects in increasing creativity.
In the 1950s and 1960s LSD was used in psychiatry to enhance psychotherapy known as psychedelic therapy. Some psychiatrists[who?] believed LSD was especially useful at helping patients to "unblock" repressed subconscious material through other psychotherapeutic methods, and also for treating alcoholism. One study concluded, "The root of the therapeutic value of the LSD experience is its potential for producing self-acceptance and self-surrender," presumably by forcing the user to face issues and problems in that individual's psyche.
Two recent reviews concluded that conclusions drawn from most of these early trials are unreliable due serious methodological flaws. These include the absence of adequate control groups, lack of followup, and vague criteria for therapeutic outcome. In many cases studies failed to convincingly demonstrate whether the drug or the therapeutic interaction was responsible for any beneficial effects.
Since 2008 there has been ongoing research in Switzerland into using LSD to alleviate anxiety for terminally ill cancer patients coping with their impending deaths.
A 2012 meta-analysis of six randomized controlled trials found evidence that a single dose of LSD in conjunction with various alcoholism treatment programs was associated with a decrease in alcohol abuse, lasting for several months, but no effect was seen at one year. Adverse events included seizure, moderate confusion and agitation, nausea, vomiting, and acting in a bizarre fashion.
In the 1950s and 1960s, psychiatrists like Oscar Janiger explored the potential effect of LSD on creativity. Experimental studies attempted to measure the effect of LSD on creative activity and aesthetic appreciation. Seventy professional artists were asked to draw two pictures of a Hopi Indian kachina doll, one before ingesting LSD and one after.
- Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 15: Reinforcement and Addictive Disorders". In Sydor A, Brown RY. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. p. 375. ISBN 9780071481274.
Several other classes of drugs are categorized as drugs of abuse but rarely produce compulsive use. These include psychedelic agents, such as lysergic acid diethylamide (LSD), which are used for their ability to produce perceptual distortions at low and moderate doses. The use of these drugs is associated with the rapid development of tolerance and the absence of positive reinforcement (Chapter 6). Partial agonist effects at 5HT2A receptors are implicated in the psychedelic actions of LSD and related hallucinogens. 3,4-Methylenedioxymethamphetamine (MDMA), commonly called ecstasy, is an amphetamine derivative. It produces a combination of psychostimulant-like and weak LSD-like effects at low doses. Unlike LSD, MDMA is reinforcing—most likely because of its interactions with dopamine systems—and accordingly is subject to compulsive abuse. The weak psychedelic effects of MDMA appear to result from its amphetamine-like actions on the serotonin reuptake transporter, by means of which it causes transporter-dependent serotonin efflux. MDMA has been proven to produce lesions of serotonin neurons in animals and humans.
- Halpern, John H.; Suzuki, Joji; Huertas,, Pedro E.; Passie, Torsten (7 June 2014). Price, Lawrence H.; Stolerman, Ian P., eds. Encyclopedia of Psychopharmacology A Springer Live Reference. Heidelberg, Germany: Springer-Verlag Berlin Heidelberg. pp. 1–5. ISBN 978-3-642-27772-6. Retrieved 24 April 2015.
Hallucinogen abuse and dependence are known complications resulting from the illicit use of drugs in this category, such as LSD and psilocybin. Users do not experience withdrawal symptoms, but the general criteria for substance abuse and dependence otherwise apply. Dependence is estimated in approximately 2 % of recent-onset users in the United States.
- Aghajanian GK, Bing OH (1964). "Persistence of lysergic acid diethylamide in the plasma of human subjects" (PDF). Clinical Pharmacology and Therapeutics 5: 611–614. PMID 14209776. Retrieved September 17, 2009.
- Papac DI, Foltz RL (May–June 1990). "Measurement of lysergic acid diethylamide (LSD) in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry" (PDF). Journal of Analytical Toxicology 14 (3): 189–190. doi:10.1093/jat/14.3.189. PMID 2374410. Retrieved September 17, 2009.
- "Definition of "amide"". Collins English Dictionary. Retrieved 2015-01-31.
- "American Heritage Dictionary Entry: amide". Ahdictionary.com. Retrieved 2015-01-31.
- "amide - definition of amide in English from the Oxford dictionary". Oxforddictionaries.com. Retrieved 2015-01-31.
- Lüscher C, Ungless MA (November 2006). "The Mechanistic Classification of Addictive Drugs". PLoS Med. 3 (11): e437. doi:10.1371/journal.pmed.0030437. PMC 1635740. PMID 17105338.
- Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A (2008). "The Pharmacology of Lysergic Acid Diethylamide: a Review" (PDF). CNS Neuroscience & Therapeutics 14 (4): 295–314. doi:10.1111/j.1755-5949.2008.00059.x. PMID 19040555.
- Hofmann, Albert. LSD—My Problem Child (McGraw-Hill, 1980). ISBN 0-07-029325-2.
- Alexander and Ann Shulgin. "LSD", in TiHKAL (Berkeley: Transform Press, 1997). ISBN 0-9630096-9-9.
- Albert Hofmann. "LSD – My Problem Child (English translation)".
- Greiner T, Burch NR, Edelberg R (1958). "Psychopathology and psychophysiology of minimal LSD-25 dosage; a preliminary dosage-response spectrum". AMA Arch Neurol Psychiatry 79 (2): 208–10. doi:10.1001/archneurpsyc.1958.02340020088016. PMID 13497365.
- "Hallucinogenic effects of LSD discovered". The History Channel.
- Arthur Stoll and Albert Hofmann LSD Patent April 30, 1943 in Switzerland and March 23, 1948 in the United States.
- "LSD: cultural revolution and medical advances". Royal Society of Chemistry. Retrieved September 27, 2007.
- Harris, Sam (2014), "The spiritual uses of pharmacology", Waking Up: A Guide to Spirituality Without Religion, Simon and Schuster, pp. 186–200, ISBN 9781451636017,
I found psilocybin and LSD to be indispensable tools, and some of the most important hours of my life were spent under their influence ... psychedelics ... often reveal, in the span of a few hours, depths of awe and understanding that can otherwise elude us for a lifetime.
- Linton Harriet B., Langs Robert J. (1962). "Subjective Reactions to Lysergic Acid Diethylamide (LSD-25)" (PDF). Arch. Gen. Psychiat 6 (5): 352–68. doi:10.1001/archpsyc.1962.01710230020003.
- Albert Hofmann. "5. From Remedy to Inebriant". LSD: My Problem Child.
...taste of metal on the palate.
- Katz MM, Waskow IE, Olsson J (1968). "Characterizing the psychological state produced by LSD". J Abnorm Psychol 73 (1): 1–14. doi:10.1037/h0020114. PMID 5639999.
- See, e.g., Gerald Oster's article "Moiré patterns and visual hallucinations". Psychedelic Rev. No. 7 (1966): 33–40.
- Liester, MB (2014). "A review of lysergic acid diethylamide (LSD) in the treatment of addictions: historical perspectives and future prospects.". Current drug abuse reviews 7 (3): 146–56. doi:10.2174/1874473708666150107120522. PMID 25563445. Retrieved 27 April 2015.
- "DrugFacts: Hallucinogens - LSD, Peyote, Psilocybin, and PCP". http://www.drugabuse.gove. National Institute on Drug Abuse. December 2014. Retrieved 17 February 2015.
- Alcohol and Drugs in North America: A Historical Encyclopedia, by David M. Fahey and Jon S. Miller, Editors, ISBN 978-1-59884-478-8, page 375
- San Francisco Chronicle September 20, 1966 Page One
- Grof, Stanislav; Joan Halifax Grof (1979). Realms of the Human Unconscious (Observations from LSD Research). London: Souvenir Press (E & A) Ltd. pp. 13–14. ISBN 0-285-64882-9.
- Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A (November 11, 2008). "The Pharmacology of Lysergic Acid Diethylamide: A Review". CNS Neuroscience & Therapeutics 14 (4): 295–314. doi:10.1111/j.1755-5949.2008.00059.x. PMID 19040555.
- Schwartz RH (1995). "LSD. Its rise, fall, and renewed popularity among high school students". Pediatric clinics of North America 42 (2): 403–13. PMID 7724266.
- Lerner AG, Gelkopf M, Skladman I, Oyffe I, Finkel B, Sigal M, Weizman A (2002). "Flashback and Hallucinogen Persisting Perception Disorder: Clinical aspects and pharmacological treatment approach". The Israel journal of psychiatry and related sciences 39 (2): 92–9. PMID 12227234.
- Halpern JH, Pope HG (2003). "Hallucinogen persisting perception disorder: What do we know after 50 years?". Drug and alcohol dependence 69 (2): 109–19. doi:10.1016/S0376-8716(02)00306-X. PMID 12609692.
- LSD AND ORGANIC BRAIN IMPAIRMENT S Cohen, AE Edwards – Drug dependence, 1969
- "Erowid LSD (Acid) Vaults: Health: Excerpt from Strassman's Adverse Reactions to Psychedelic Drugs". Erowid.org. March 25, 1993. Retrieved November 27, 2010.
- "Is Military Research Hazardous to Veterans Health? Lessons Spanning Half A Century, part F. HALLUCINOGENS". December 8, 1994 John D. Rockefeller IV, West Virginia: 103rd Congress, 2nd Session-S. Prt. 103-97; Staff Report prepared for the committee on veterans' affairs. December 8, 1994.
- Middlefell R (March 1967). "The effects of LSD on body sway suggestibility in a group of hospital patients" (PDF). Br J Psychiatry 113 (496): 277–80. doi:10.1192/bjp.113.496.277. PMID 6029626.
- Sjoberg BM, Hollister LE (November 1965). "The effects of psychotomimetic drugs on primary suggestibility". Psychopharmacologia 8 (4): 251–62. doi:10.1007/BF00407857. PMID 5885648.
- Strassman RJ (1984). "Adverse reactions to psychedelic drugs. A review of the literature". J Nerv Ment Dis 172 (10): 577–95. doi:10.1097/00005053-198410000-00001. PMID 6384428.
- Blumenfield M (1971). "Flashback phenomena in basic trainees who enter the US Air Force". Military Medicine 136 (1): 39–41. PMID 5005369.
- Naditch MP, Fenwick S (1977). "LSD flashbacks and ego functioning". Journal of Abnormal Psychology 86 (4): 352–9. doi:10.1037/0021-843X.86.4.352. PMID 757972.
- Edward, Brecher. "The Consumers Union Report on Licit and Illicit Drugs (1971): Chapter 51".
- Abraham HD, Aldridge AM (1993). "Adverse consequences of lysergic acid diethylamide". Addiction (Abingdon, England) 88 (10): 1327–34. doi:10.1111/j.1360-0443.1993.tb02018.x. PMID 8251869.
- Abraham HD, Aldridge AM (1993). "Adverse consequences of lysergic acid diethylamide". Addiction 88 (10): 1327–34. doi:10.1111/j.1360-0443.1993.tb02018.x. PMID 8251869.
- Halpern JH, Pope HG (2003). "Hallucinogen persisting perception disorder: what do we know after 50 years?". Drug Alcohol Depend 69 (2): 109–19. doi:10.1016/S0376-8716(02)00306-X. PMID 12609692.
- Halpern JH (2003). "Hallucinogens: an update". Curr Psychiatry Rep 5 (5): 347–54. doi:10.1007/s11920-003-0067-4. PMID 13678554.
- Li JH, Lin LF (November 1998). "Genetic toxicology of abused drugs: a brief review.". Mutagenesis 13 (6): 557–565. doi:10.1093/mutage/13.6.557. PMID 9862186.
- "Gross behavioural changes in monkeys following administration of LSD-25, and development of tolerance to LSD-25 – Springer". link.springer.com. Retrieved September 25, 2014.
- Wolbach AB, Isbell H, Miner EJ (1962). "Cross tolerance between mescaline and LSD-25, with a comparison of the mescaline and LSD reactions". Psychopharmacologia 3: 1–14. doi:10.1007/BF00413101. PMID 14007904.
- Isbell H, Wolbach AB, Wikler A, Miner EJ (1961). "Cross Tolerance between LSD and Psilocybin". Psychopharmacologia 2 (3): 147–59. doi:10.1007/BF00407974. PMID 13717955.
- McKenna DJ, Nazarali AJ, Himeno A, Saavedra JM (1989). "Chronic treatment with (+/-)DOI, a psychotomimetic 5-HT2 agonist, downregulates 5-HT2 receptors in rat brain". Neuropsychopharmacology 2 (1): 81–87. doi:10.1016/0893-133X(89)90010-9. PMID 2803482.
- Buckholtz NS, Zhou DF, Freedman DX, Potter WZ (1990). "Lysergic acid diethylamide (LSD) administration selectively downregulates serotonin2 receptors in rat brain". Neuropsychopharmacology 3 (2): 137–148. PMID 1969270.
- Brenner S & Corden TE (March 22, 2012). "LSD Toxicity Treatment & Management". Medscape. Retrieved April 27, 2012.
- Coma, Hyperthermia and Bleeding Associated with Massive LSD Overdose West J Med. 1974 Mar; 120(3): 183–188. PMCID: PMC1129381
- Marona-Lewicka D, Thisted RA, Nichols DE (2005). "Distinct temporal phases in the behavioral pharmacology of LSD: Dopamine D2 receptor-mediated effects in the rat and implications for psychosis". Psychopharmacology 180 (3): 427–435. doi:10.1007/s00213-005-2183-9. PMID 15723230.
- Nichols, David (November 2012). "The End of a Chemistry Era... Dave Nichols Closes Shop". Retrieved September 24, 2013.
- Nichols DE (2004). "Psychotropics". Pharmacology & Therapeutics 101 (2): 131–81. doi:10.1016/j.pharmthera.2003.11.002. PMID 14761703.
- "PDSP database". Retrieved June 28, 2013.
- Nelson DL (February 2004). "5-HT5 receptors". Current drug targets. CNS and neurological disorders 3 (1): 53–8. doi:10.2174/1568007043482606. PMID 14965244.
- Moreno JL et al. (2011). "Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists". Neurosci Lett. 76 (3): 76–79. doi:10.1016/j.neulet.2011.01.046. PMC 3064746. PMID 21276828.
- Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB (June 27, 2006). "Functional Selectivity and Classical Concepts of Quantitative Pharmacology". JPET 320 (1): 1–13. doi:10.1124/jpet.106.104463. PMID 16803859.
- BilZ0r. "The Neuropharmacology of Hallucinogens: a technical overview". Erowid, v3.1 (August 2005).
- Svenningsson P, Nairn AC, Greengard P (2005). "DARPP-32 mediates the actions of multiple drugs of abuse". AAPS Journal 7 (2): E353–E360. doi:10.1208/aapsj070235. PMC 2750972. PMID 16353915.
- Borroto-Escuela DO et al. (2014). "Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes.". Biochem Biophys Res Commun 278 (1): 278–84. doi:10.1016/j.bbrc.2013.11.104. PMID 24309097.
- Monte AP, Marona-Lewicka D, Kanthasamy A, Sanders-Bush E, Nichols DE (March 1995). "Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes". Journal of Medicinal Chemistry 38 (6): 958–66. doi:10.1021/jm00006a015. PMID 7699712.
- Nichols DE, Frescas S, Marona-Lewicka D, Kurrasch-Orbaugh DM (September 2002). "Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD)". Journal of Medicinal Chemistry 45 (19): 4344–9. doi:10.1021/jm020153s. PMID 12213075.
- "Erowid Morning Glory Vaults : Extraction of LSA (Method #1)". erowid.org. Retrieved September 25, 2014.
- Kornfeld, Edmund C.; Fornefeld, E. J.; Kline, G. Bruce; Mann, Marjorie J.; Morrison, Dwight E.; Jones, Reuben G.; Woodward, R. B. (1956). "The Total Synthesis of Lysergic Acid". Journal of the American Chemical Society 78 (13): 3087–3114. doi:10.1021/ja01594a039.
- Inuki S, Oishi S, Fujii N, Ohno H (2008). "Total Synthesis of (±)-Lysergic Acid, Lysergol, and Isolysergol by Palladium-Catalyzed Domino Cyclization of Amino Allenes Bearing a Bromoindolyl Group". Organic Letters 10 (22): 5239–5242. doi:10.1021/ol8022648. PMID 18956869.
- Stoll, W.A. (1947). "Ein neues, in sehr kleinen Mengen wirsames Phantastikum". Arch. Neur. (Schweiz) 60: 483.
- Erowid & Eduardo Hidalgo, Energy Control (Spain) (2009). "LSD Samples Analysis". Erowid. Retrieved February 8, 2010.
- Henderson, Leigh A.; Glass, William J. (1994). LSD: Still with us after all these years. San Francisco: Jossey-Bass. ISBN 978-0-7879-4379-0.
- Fire & Earth Erowid (2003). "LSD Analysis – Do we know what's in street acid?". Erowid. Retrieved February 8, 2010.
- Li Z, McNally AJ, Wang H, Salamone SJ (October 1998). "Stability study of LSD under various storage conditions". J. Anal. Toxicol. 22 (6): 520–5. doi:10.1093/jat/22.6.520. PMID 9788528.
- R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 871–874.
- Hofmann 1980, p. 15
- Albert Hofmann; translated from the original German (LSD Ganz Persönlich) by J. Ott. MAPS-Volume 6, Number 69, Summer 1969
- Nichols, David (May 24, 2003). "Hypothesis on Albert Hofmann's Famous 1943 "Bicycle Day"". Hofmann Foundation. Retrieved September 27, 2007.
- Albert Hofmann. "LSD My Problem Child". Retrieved April 19, 2010.
- Hofmann, Albert. "History Of LSD". Retrieved September 27, 2007.
- DEA Public Affairs (November 16, 2001). "LSD: The Drug". Web.petabox.bibalex.org. Retrieved November 27, 2010.
- "Brecher, Edward M; et al. (1972). "How LSD was popularized". Consumer Reports/Drug Library". Druglibrary.org. Retrieved June 20, 2012.
- United States Congress (October 24, 1968). "Staggers-Dodd Bill, Public Law 90-639" (PDF). Retrieved September 8, 2009.
- Gasser, Peter (1994). "Psycholytic Therapy with MDMA and LSD in Switzerland". Retrieved September 8, 2009.
- UN Convention on Psychotropic Substances, 1971 Final act of the United Nations Conference
- Canadian government (1996). "Controlled Drugs and Substances Act". Justice Laws. Canadian Department of Justice. Retrieved December 15, 2013.
- Drugs and the law: Report of the inquiry into the Misuse of Drugs Act 1971 London: Police Foundation, 2000, Runciman Report
- After the War on Drugs: Blueprint for Regulation Transform Drug Policy Foundation 2009
- From : LSD is a Schedule I substance under the Controlled Substances Act.
- "Toxicity, Hallucinogens – LSD". Emedicine.medscape.com. Retrieved November 27, 2010.
- Neal v. United States, U.S. 284 (1996). , originating from U.S. v. Neal, 46 F.3d 1405 (7th Cir. 1995)
- DEA (2007). "LSD Manufacture – Illegal LSD Production". LSD in the United States. U.S. Department of Justice Drug Enforcement Administration. Archived from the original on August 29, 2007.
- Stafford, Peter (1992). "Chapter 1 – The LSD Family". Psychedelics Encyclopaedia (Third Expanded ed.). Ronin Publishing Inc. p. 62. ISBN 0-914171-51-8.
- Laing, Richard R.; Barry L. Beyerstein; Jay A. Siegel (2003). "Chapter 2.2 – Forms of the Drug". Hallucinogens: A Forensic Drug Handbook. Academic Press. pp. 39–41. ISBN 0-12-433951-4.
- Honig, David. Frequently Asked Questions via Erowid
- "Street Terms: Drugs and the Drug Trade". Office of National Drug Control Policy. April 5, 2005. Retrieved January 31, 2007.
- DEA (2008). "Photo Library (page 2)". US Drug Enforcement Administration. Retrieved June 27, 2008.[dead link]
- ^ Maclean, J.R.; Macdonald, D.C.; Ogden, F.; Wilby, E., "LSD-25 and mescaline as therapeutic adjuvants." In: Abramson, H., Ed., The Use of LSD in Psychotherapy and Alcoholism, Bobbs-Merrill: New York, 1967, pp. 407–426; Ditman, K.S.; Bailey, J.J., "Evaluating LSD as a psychotherapeutic agent," pp.74–80; Hoffer, A., "A program for the treatment of alcoholism: LSD, malvaria, and nicotinic acid," pp. 353–402.
- ^ LSD: The Drug
- United States Drug Enforcement Administration (October 2005). "LSD BLOTTER ACID MIMIC CONTAINING 4-BROMO-2, 5-DIMETHOXY-AMPHETAMINE (DOB) SEIZED NEAR BURNS, OREGON" (PDF). Microgram Bulletin 38 (10). Retrieved August 20, 2009.
- United States Drug Enforcement Administration (November 2006). ""PURPLE" (COUGH SYRUP CONTAINING CODEINE AND OXYCODONE) IN WILKINSBURG, PENNSYLVANIA" (PDF). Microgram Bulletin 39 (11). Retrieved August 20, 2009.
- United States Drug Enforcement Administration (March 2008). "UNUSUAL "RICE KRISPIE TREAT"-LIKE BALLS CONTAINING PSILOCYBE MUSHROOM PARTS IN WARREN COUNTY, MISSOURI" (PDF). Microgram Bulletin 41 (3). Retrieved August 20, 2009.
- Iversen, Les (May 29, 2013). "Temporary Class Drug Order Report on 5-6APB and NBOMe compounds" (PDF). Advisory Council on the Misuse of Drugs. Gov.Uk. p. 14. Retrieved 16 June 2013.
- United States Drug Enforcement Administration (March 2009). ""SPICE" – PLANT MATERIAL(S) LACED WITH SYNTHETIC CANNABINOIDS OR CANNABINOID MIMICKING COMPOUNDS" (PDF). Microgram Bulletin 42 (3). Retrieved August 20, 2009.
- United States Drug Enforcement Administration (November 2005). "BULK MARIJUANA IN HAZARDOUS PACKAGING IN CHICAGO, ILLINOIS" (PDF). Microgram Bulletin 38 (11). Retrieved August 20, 2009.
- United States Drug Enforcement Administration (December 2007). "SMALL HEROIN DISKS NEAR GREENSBORO, GEORGIA" (PDF). Microgram Bulletin 40 (12). Retrieved August 20, 2009.
- "The Albert Hofmann Foundation". Hofmann Foundation. Retrieved September 27, 2007.
- "LSD & Psilocybin-Assisted Therapy for Anxiety". Retrieved October 16, 2013.
- DEA Public Affairs (November 16, 2001). "DEA – Publications – LSD in the US – The Drug". Web.petabox.bibalex.org. Retrieved November 27, 2010.
- Bogenschutz MP (2013). "Studying the effects of classic hallucinogens in the treatment of alcoholism: Rationale, methodology, and current research with psilocybin". Current drug abuse reviews 6 (1): 17–29. doi:10.2174/15733998113099990002. PMID 23627783.
- Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A (2008). "The pharmacology of lysergic acid diethylamide: A review". CNS Neuroscience & Therapeutics 14 (4): 295–314. doi:10.1111/j.1755-5949.2008.00059.x. PMID 19040555.
- Sessa B (2008). "Is it time to revisit the role of psychedelic drugs in enhancing human creativity?". Journal of Psychopharmacology 22 (8): 821–7. doi:10.1177/0269881108091597. PMID 18562421.
- Cohen, S. (1959). The therapeutic potential of LSD-25. A Pharmacologic Approach to the Study of the Mind, p251–258.
- "Use of d-lysergic acid diethylamide in the treatment of alcoholism". Retrieved June 20, 2012.
- "Use of d-Lysergic Acid Diethylamide in the Treatment of Alcoholism". Hofmann.org. November 14, 2003. Retrieved February 22, 2012.
- Chwelos N, Blewett DB, Smith CM, Hoffer A (1959). "Use of d-lysergic acid diethylamide in the treatment of alcoholism". Quart. J. Stud. Alcohol 20: 577–90. PMID 13810249.
- Vollenweider, F. X.; Kometer, M (2010). "The neurobiology of psychedelic drugs: Implications for the treatment of mood disorders". Nature Reviews Neuroscience 11 (9): 642–51. doi:10.1038/nrn2884. PMID 20717121.
- Baumeister, D; Barnes, G; Giaroli, G; Tracy, D (2014). "Classical hallucinogens as antidepressants? A review of pharmacodynamics and putative clinical roles". Therapeutic Advances in Psychopharmacology 4 (4): 156–69. doi:10.1177/2045125314527985. PMC 4104707. PMID 25083275.
- "Psychiater Gasser bricht sein Schweigen". July 28, 2009.
- Krebs TS, Johansen PØ (March 8, 2012). "Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials" (PDF). Journal of Psychopharmacology (Jop.sagepub.com) 26 (7): 994–1002. doi:10.1177/0269881112439253. PMID 22406913. Retrieved June 20, 2012.
- Kast E (1967). "Attenuation of anticipation: a therapeutic use of lysergic acid diethylamide" (PDF). Psychiat. Quart. 41 (4): 646–57. doi:10.1007/BF01575629. PMID 4169685.
- Berlin pilot cluster headaches treatment with LSD study. LSD Alleviates 'Suicide Headaches'.
- Sessa B (2008). "Is it time to revisit the role of psychedelic drugs in enhancing human creativity?". J Psychopharmacol 22 (8): 821–7. doi:10.1177/0269881108091597. PMID 18562421.
- Janiger O, Dobkin de Rios M (1989). "LSD and creativity". J Psychoactive Drugs 21 (1): 129–34. doi:10.1080/02791072.1989.10472150. PMID 2723891.
- Stafford, Peter G.; B. H. Golightly (1967). LSD, the problem-solving psychedelic. ASIN B0006BPSA0.
- McGlothlin W, Cohen S, McGlothlin MS (1967). "Long lasting effects of LSD on normals" (PDF). Archives of General Psychiatry 17 (5): 521–532. doi:10.1001/archpsyc.1967.01730290009002. PMID 6054248.
- Whalen, John (July 9, 1998). "The Trip: Cary Grant on acid, and other stories from the LSD Studies of Dr. Oscar Janiger". LA Weekly.
- Marks, John. The Search for the Manchurian Candidate: The CIA and Mind Control (1979), ISBN 0-8129-0773-6
- Hofmann, Albert. LSD My Problem Child: Reflections on Sacred Drugs, Mysticism and Science (1983) ISBN 978-0-9660019-8-3
- Lee, Martin A. and Bruce Shlain. Acid Dreams: The Complete Social History of LSD: The CIA, the Sixties, and Beyond (1992) ISBN 978-0-8021-3062-4
- Henderson, Leigh A. and William J. Glass. LSD: Still With Us After All These Years: Based on the National Institute of Drug Abuse Studies on the Resurgence of Contemporary LSD Use (1st edition 1994, 2nd edition 1998) ISBN 978-0-7879-4379-0
- Stevens, Jay. Storming Heaven: LSD And The American Dream (1998) ISBN 978-0-8021-3587-2
- Grof, Stanislav. LSD Psychotherapy. (April 10, 2001)
- de Rios, Marlene Dobkin and Oscar Janiger. LSD, spirituality, and the creative process (2003, Inner Traditions) ISBN 978-0-89281-973-7 – "An exploration of how LSD influences imagination and the creative process. Based on the results of one of the longest clinical studies of LSD that took place between 1954 and 1962, before LSD was illegal. Includes personal reports, artwork, and poetry from the original sessions as testimony of the impact of LSD on the creative process."
- Roberts, Andy. Albion Dreaming: A Popular History of LSD in Britain (2008), Marshall Cavendish, U.K, ISBN 1-905736-27-4
- Bebergal, Peter, "Will Harvard drop acid again? Psychedelic research returns to Crimsonland", The Phoenix (Boston), June 2, 2008
- Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A (2008). "The pharmacology of lysergic acid diethylamide: a review". CNS Neuroscience & Therapeutics 14 (4): 295–314. doi:10.1111/j.1755-5949.2008.00059.x. PMID 19040555.
- BBC News: Pont-Saint-Esprit poisoning: Did the CIA spread LSD? (2010)
- Dale Bewan. Dropping Acid: A Beginner's Guide to the Responsible Use of LSD for Self-Discovery (1st edition 2013) ISBN 1492318191
|Wikiquote has quotations related to: LSD|
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- Drug Profiles: LSD European Monitoring Centre for Drugs and Drug Addiction
- LSD-25 at Erowid
- The Lycaeum Archive: LSD
- LSD entry in TiHKAL • info
- InfoFacts – Hallucinogens NIDA
- Scholarly bibliography on the histories of LSD use
- LSD Returns-For Psychotherapeutics (Scientific American Magazine article)
- U.S. National Library of Medicine: Drug Information Portal – Lysergic acid diethylamide
- My LSD Trip: a non-cop, non-hippie report of the unvarnished facts, by Robert Gannon, Popular Science Magazine, December 1967.
- WWW Psychedelic Bibliography, MAPS – large database of scientific publications on LSD and other psychedelics, fulltext PDFs
- Hofmann's Potion a documentary on the origins of LSD
- Power & Control LSD in The Sixties on YouTube, documentary film directed by Aron Ranen, 2006
- Inside LSD National Geographic Channel, 2009