LSM5

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
LSM5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLSM5, YER146W, LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDsOMIM: 607285 MGI: 1913623 HomoloGene: 40833 GeneCards: LSM5
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for LSM5
Genomic location for LSM5
Band7p14.3Start32,485,338 bp[1]
End32,495,283 bp[1]
RNA expression pattern
PBB GE LSM5 202903 at fs.png

PBB GE LSM5 202904 s at fs.png

PBB GE LSM5 211747 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130710
NM_001139499
NM_012322

NM_025520

RefSeq (protein)

NP_001124182
NP_001132971
NP_036454

NP_079796

Location (UCSC)Chr 7: 32.49 – 32.5 MbChr 6: 56.7 – 56.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

U6 snRNA-associated Sm-like protein LSm5 is a protein that in humans is encoded by the LSM5 gene.[5][6][7]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106355 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000091625 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
  6. ^ Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T (Jan 2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726 (inactive 2019-08-20). PMC 1370355. PMID 12515382.
  7. ^ a b "Entrez Gene: LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

Further reading[edit]