|Trade names||Importal, Pizensy, Lacty|
|Other names||Lactitol Hydrate (JAN JP)|
|E number||E966 (glazing agents, ...)|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||344.313 g·mol−1|
|3D model (JSmol)|
|Melting point||146 °C (295 °F)|
Lactitol is a sugar alcohol used as a replacement bulk sweetener for low calorie foods with 30–40% of the sweetness of sucrose. It is also used medically as a laxative. Lactitol is produced by two manufacturers, Danisco and Purac Biochem.[not verified in body]
Lactitol is used in a variety of low food energy or low fat foods. High stability makes it popular for baking. It is used in sugar-free candies, cookies (biscuits), chocolate, and ice cream, with a sweetness of 30–40% that of sucrose. Lactitol also promotes colon health as a prebiotic. Because of poor absorption, lactitol only has 2–2.5 kilocalories (8.4–10.5 kilojoules) per gram, compared to 4 kilocalories (17 kJ) per gram for typical saccharides. Hence, lactitol is about 60% as caloric as typical saccharides.
Safety and health
Lactitol, erythritol, sorbitol, xylitol, mannitol, and maltitol are all sugar alcohols.[medical citation needed] The U.S. Food and Drug Administration (FDA) classifies sugar alcohols as "generally recognized as safe" (GRAS).[medical citation needed] They are approved as food additives, and are recognized as not contributing to tooth decay or causing increases in blood glucose.[medical citation needed] Lactitol is also approved for use in foods in most countries around the world.[medical citation needed]
Like other sugar alcohols, lactitol causes cramping, flatulence, and diarrhea in some individuals who consume it. This is because humans lack a suitable beta-galactosidase in the upper gastrointestinal (GI) tract, and a majority of ingested lactitol reaches the large intestine, where it then becomes fermentable to gut microbes (prebiotic) and can pull water into the gut by osmosis.[medical citation needed] Those with health conditions should consult their GP or dietician prior to consumption.[medical citation needed]
The U.S. Food and Drug Administration (FDA) approved Pizensy based on evidence from a clinical trial (Trial 1/ NCT02819297) of 594 subjects with CIC conducted in the United States. The FDA also considered other supportive evidence including data from Trial 2 (NCT02481947) which compared Pizensy to previously approved drug (lubiprostone) for CIC, and Trial 3 (NCT02819310) in which subjects used Pizensy for one year as well as data from published literature.
The benefit and side effects of Pizensy were evaluated in a clinical trial (Trial 1) of 594 subjects with CIC. In this trial, subjects received treatment with either Pizensy or placebo once daily for 6 months. Neither the subjects nor the health care providers knew which treatment was being given until after the trials were completed.
In the second trial (Trial 2) of three months duration, improvement in CSBMs was used to compare Pizensy to the drug lubiprostone which was previously approved for CIC. The third trial (Trial 3) was used to collect the side effects in subjects treated with Pizensy for one year.
- Gränzle, M.G. (2011). "Lactose and Oligosaccharides | Lactose: Derivatives". Encyclopedia of Dairy Sciences (2nd ed.). Elsevier Ltd. pp. 202–208. doi:10.1016/B978-0-12-374407-4.00275-2. ISBN 9780123744074.
- "Lactitol (Inactive Ingredient)". Drugs.com. 23 September 2018. Retrieved 24 February 2020.
- "Lactitol Monohydrate (Inactive Ingredient)". Drugs.com. 3 October 2018. Retrieved 24 February 2020.
- Miller LE, Tennilä J, Ouwehand AC (2014). "Efficacy and tolerance of lactitol supplementation for adult constipation: a systematic review and meta-analysis". Clin Exp Gastroenterol. 7: 241–8. doi:10.2147/CEG.S58952. PMC 4103919. PMID 25050074.
- "Importal". Drugs.com. 3 February 2020. Retrieved 24 February 2020.
- FASS.se (the Swedish Medicines Information Engine). Revised 2003-02-12.
- "Pizensy: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 24 February 2020.
- "Pizensy- lactitol powder, for solution". DailyMed. 21 February 2020. Retrieved 24 February 2020.
- "Drug Trial Snapshot: Pizensy". U.S. Food and Drug Administration (FDA). 12 February 2020. Retrieved 4 March 2020. This article incorporates text from this source, which is in the public domain.
- Grimble GK, Patil DH, Silk DB (1988). "Assimilation of lactitol, an unabsorbed disaccharide in the normal human colon". Gut. 29 (12): 1666–1671. doi:10.1136/gut.29.12.1666. PMC 1434111. PMID 3220306.