Lactobacillus crispatus

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Lactobacillus crispatus
Scientific classification
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: L. crispatus
Binomial name
Lactobacillus crispatus

Lactobacillus crispatus is a common, rod-shaped species of genus Lactobacillus and is a hydrogen peroxide [1] producing (H2O2) beneficial micro biota species located in both the vagina, through vaginal discharge, and the vertebrate gastrointestinal.[2] The strain CTV-05 is used as a probiotic that can be used by premenopausal and postmenopausal women[3] that experience recurrent urinary tract infections. It is being evaluated specifically for the prevention and treatment of bacterial vaginosis,[4] which is characterized by the absence of lactobacillus flora, also known as Lactobacillus acidophilus; which plays a large role in protecting the host from infection.[5]


Lactobacillus crispatus is a species in the phylum Firmicutes, in the class Bacilli, in the order Lactobacillales, in the family Lactobacillaceae and the genus Lactobaccillus.[6] It is one of one hundred twenty two other species identified within the genus. It is made up of about 2,043,161 nucleotides[7] that make up its length of 2,021 protein genes,[8] 76 RNA genes [9] and has a circular chromosomal shape.[10] The strain of Lactobacillus crispastus was originally isolated from a pouch in chickens gullet[11] where food is stored and is considered to be one of the strongest H2O2-producing Lactobacilli. However, like many other Lactobacilli species, it can be severely altered by changes to the immune system, hormone levels and from the use of antimicrobials.

How it is used[edit]

CTV-05 gelatin suppository capsules[12] are inserted into the vagina as a probiotic that can help maintain healthy flora. Studies have shown that L. crispastus CTV-05 effectively colonized the vagina and helped prevent and treat recurrent bacterial vaginosis and other genital infections. Scientists have stated that evidence from clinical trials proves that that these probiotics will safely and effectively treat bacterial vaginosis if used alone or alongside an antibiotic treatment if an infection had already arisen.[13] Condom use has showed increased colonization of Lactobacillus crispastus in the vagina because it protects against both bacterial vaginosis (BV) and human immunodeficiency virus (HIV).[14]