In October 1998, 1,000 copies of the single were released on white vinyl. In 2001, a second edition of 1,000 black vinyl were released. Today, it is extremely rare and expensive, fetching high prices on auction websites like eBay. A large number of copies of White Blood Cells, The White Stripes' third album were packaged with a bonus DVD which featured an audio track of "Lafayette Blues" (as well as "Hand Springs").
The lyrics of "Lafayette Blues" are a list of French names of streets in the band's hometown, Detroit, Michigan. Live performances of "Lafayette Blues" contain various arrangements of the names.