Lake Pohenegamook (Lac Pohénégamook) is a Canadian lake located in southeastern Quebec immediately north of the International Boundary with Maine (at Aroostook County).
Oriented north-south, the lake is nestled in a valley in the Notre Dame Mountains, part of the Appalachian Range. Route 289 runs along the southern and western shores through the municipality of Pohénégamook - an amalgamation of several villages.
The National Transcontinental Railway constructed its mainline from Winnipeg to Moncton along the western and southern shores in 1912 - today this line forms the mainline of CN Rail between Halifax and Montreal.
The community of Estcourt Station, Maine (the northernmost point in New England) is located immediately south of the CN railway line at the lake's southern shore.