Lake Tsimanampetsotsa (French: Lac Tsimanampetsotsa) is a saline lake in the Toliara Province, southwestern part of Madagascar. It is located at around 24°07′S 43°45′E / 24.117°S 43.750°E. The lake is an important wetland and it is protected within a national park and as a Ramsar site. Ramsar site has a total area of 456.00 km² while the surface of the lake is much smaller. The lake Tsimanampetsotsa is a part of the Tsimanampetsotsa National Park.
Lake of the name in Malagasy means "lake without dolphins".