The Lakes-to-Sea Highway, also known as the "Ship-to-Shore" highway, was an auto trail in the Northeast U.S., running from Erie, Pennsylvania (on Lake Erie) southeast via Harrisburg and Philadelphia to Atlantic City, New Jersey (on the Atlantic Ocean – the "sea").
The highway roughly followed the following present routes:
- U.S. Route 19, Erie to Meadville
- U.S. Route 322, Meadville to West Chester
- Pennsylvania Route 3, West Chester to Philadelphia
- U.S. Route 30, Philadelphia to Atlantic City
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