The area was originally developed with wells and a recreation ground, with houses following in the 19th century. 
After some bomb damage during the Blitz in World War II on 18 September 1940, the area became rather run down and was subsequently rebuilt. Some older buildings are still present, including the Henry Moore Sculpture Studios, image adjacent.
Lambeth Walk starts as a turning off the Lambeth Road (A3203) between Kennington Road and the main railway line into London Waterloo station. On the junction with Lambeth Road is the former Lambeth Walk pub. On the opposite corner is the modern hall of the Lambeth Mission church (now shared with St Mary's church) and International House, now a hall of residence of the University of Westminster.
Turning into Lambeth Walk, at no 5 is the Lambeth Walk Group Practice, a local NHS health centre run for many years by King's College London. The practice relocated to the site in 1996; the building was converted from a former public laundry and slipper baths. 
The Chandler Community Hall at 15 Lambeth Walk serves the adjacent China Walk estate, a London County Council estate where the houses are named after different china manufacturers, including Wedgwood, Derby and Doulton. A plaque on the Hall commemorates Charlie Chaplin whose early years were spent nearby.
Next to the Chandler Community Hall is the Pelham Hall, now the sculpture department of Morley College. This was the original Lambeth Mission hall, built in about 1910, with a distinctive outside pulpit. 
Continuing southeast of Fitzalan Street and Juxon Street, Lambeth Walk is flanked by modern social housing, built partly on the site of the former Norfolk House, home of the Duke of Norfolk, on Old Paradise Street.  Fitzalan Street, off Lambeth Walk, takes its name from the Norfolk ducal family, while Juxon Street is named after Archbishop William Juxon, former resident of Lambeth Palace.
Lambeth Walk Doorstep Green, a small park, is between Fitzalan and Lollard Streets. The former boiler house at Sugden House on the corner of Old Paradise Street was redeveloped for housing; the chimney was preserved as a local landmark.
Lambeth Walk ends at Black Prince Road, opposite the Jolly Gardeners pub.
Anytime you're Lambeth way
Any evening, any day,
You'll find us all doin' the Lambeth walk.
Forty-year old housewife Mrs Elizabeth Walk of Lambeth Walk
Had a husband who was jubblified with only half a stalk
So she had a Milk of Magnesia and curry powder sandwich,
Half a pound of uncut pork
Took an overdose of Omo, this made the neighbours talk
- "Lambeth Walk street market". Vauxhall History Online Archive.
- "Lambeth Walk". Vauxhall Society.
- "About us". Lambeth Walk GP.
- "Doing the Lambeth Walk". PJ Online. Archived from the original on 7 May 2014.
- Sir Howard Roberts and Walter H. Godfrey (editors) (1951). "The Walcot Estate". Survey of London: volume 23: Lambeth: South Bank and Vauxhall. Institute of Historical Research.
- Sir Howard Roberts and Walter H. Godfrey (editors) (1951). "Norfolk House and Old Paradise Street". Survey of London: volume 23: Lambeth: South Bank and Vauxhall. Institute of Historical Research.
- Lambeth Walk information from the Vauxhall Society
- Lambeth Walk, In Their Shoes from the Partleton Tree
- grid reference