Laminin, alpha 2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Available structures
PDB Ortholog search: PDBe RCSB
Aliases LAMA2, LAMM, Laminin, alpha 2, laminin subunit alpha 2
External IDs MGI: 99912 HomoloGene: 37306 GeneCards: 3908
Genetically Related Diseases
Disease Name References
amyotrophic lateral sclerosis
refractive error
RNA expression pattern
PBB GE LAMA2 205116 at tn.png

PBB GE LAMA2 213519 s at tn.png

PBB GE LAMA2 216840 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 128.88 – 129.52 Mb Chr 10: 26.98 – 27.62 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene.[1][2][3]


Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.[3]


  1. ^ Ehrig K, Leivo I, Argraves WS, Ruoslahti E, Engvall E (Jun 1990). "Merosin, a tissue-specific basement membrane protein, is a laminin-like protein". Proc Natl Acad Sci U S A 87 (9): 3264–8. doi:10.1073/pnas.87.9.3264. PMC 53880. PMID 2185464. 
  2. ^ Vuolteenaho R, Nissinen M, Sainio K, Byers M, Eddy R, Hirvonen H, Shows TB, Sariola H, Engvall E, Tryggvason K (Feb 1994). "Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues". J Cell Biol 124 (3): 381–94. doi:10.1083/jcb.124.3.381. PMC 2119934. PMID 8294519. 
  3. ^ a b "Entrez Gene: LAMA2 laminin, alpha 2 (merosin, congenital muscular dystrophy)". 

Further reading[edit]

External links[edit]