Laminin, alpha 2

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Laminin, alpha 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LAMA2 ; LAMM
External IDs OMIM156225 MGI99912 HomoloGene37306 GeneCards: LAMA2 Gene
RNA expression pattern
PBB GE LAMA2 205116 at tn.png
PBB GE LAMA2 213519 s at tn.png
PBB GE LAMA2 216840 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3908 16773
Ensembl ENSG00000196569 ENSMUSG00000019899
UniProt P24043 Q60675
RefSeq (mRNA) NM_000426 NM_008481
RefSeq (protein) NP_000417 NP_032507
Location (UCSC) Chr 6:
128.88 – 129.52 Mb
Chr 10:
26.98 – 27.62 Mb
PubMed search [1] [2]

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene.[1][2][3]


Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.[3]


  1. ^ Ehrig K, Leivo I, Argraves WS, Ruoslahti E, Engvall E (Jun 1990). "Merosin, a tissue-specific basement membrane protein, is a laminin-like protein". Proc Natl Acad Sci U S A 87 (9): 3264–8. doi:10.1073/pnas.87.9.3264. PMC 53880. PMID 2185464. 
  2. ^ Vuolteenaho R, Nissinen M, Sainio K, Byers M, Eddy R, Hirvonen H, Shows TB, Sariola H, Engvall E, Tryggvason K (Feb 1994). "Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues". J Cell Biol 124 (3): 381–94. doi:10.1083/jcb.124.3.381. PMC 2119934. PMID 8294519. 
  3. ^ a b "Entrez Gene: LAMA2 laminin, alpha 2 (merosin, congenital muscular dystrophy)". 

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