Louis played four years of football at San Diego State, playing tight end as a sophomore, guard as a junior, and started all twelve games senior year at right tackle. In March 2010 he plea guilty to a misdemenour assault charge relating to a fight with a teammate in a meeting room. He was sentenced to three years of informal probation and a $565 fine.
After not being invited to the NFL Combine, Louis was determined to perform admirably at SDSU's pro day. He lived up to the task, weighing in at 303 pounds and running a 4.76 second 40. He was drafted in the seventh round of the 2009 NFL Draft by the Chicago Bears. 2012 In Week 7, Louis recorded his first reception off a tipped pass from quarterback Jay Cutler. In Week 12 of the 2012 season against the Minnesota Vikings, Louis tore his left ACL after getting blindsided by Jared Allen, and was placed on injured reserve. Allen was fined $20,000 for the hit.