The headwaters of the Landor rise north of Mount Erong and flows generally north, joined by two minor tributaries; Flinerty Creek and Fleury Creek. The river forms confluence with the Gascoyne River near the Landor Station homestead. The river descends 37 metres (121 ft) over its 32-kilometre (20 mi) course.
The first European to discover the river was the surveyor, Henry Carey in 1882. It is thought that he named the river after a prominent Perth barrister, E. W. Landor.