Langerin

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CD207
Protein CD207 PDB 3C22.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD207, CLEC4K, CD207 molecule
External IDsOMIM: 604862 MGI: 2180021 HomoloGene: 9252 GeneCards: CD207
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CD207
Genomic location for CD207
Band2p13.3Start70,830,214 bp[1]
End70,835,822 bp[1]
RNA expression pattern
PBB GE CD207 220428 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015717

NM_144943

RefSeq (protein)

NP_056532

NP_659192

Location (UCSC)Chr 2: 70.83 – 70.84 MbChr 6: 83.67 – 83.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene.[5][6] Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.[6][7]

Function[edit]

The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it is known by the name C-type lectin domain family 4 member K (CD antigen CD207). It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.[5]

Clinical significance[edit]

Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.[8][9]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116031 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034783 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b EntrezGene 50489
  6. ^ a b Valladeau J; Ravel O; Dezutter-Dambuyant C; Moore K; Kleijmeer M; Liu Y; Duvert-Frances Vé; Vincent C; Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity. 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
  7. ^ Valladeau J; Clair-Moninot Vé; Dezutter-Dambuyant C; Pin J-J; Kissenpfennig A; Mattéi M-G; Ait-Yahia S; Bates EEM; Malissen B (2002). "Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues". Journal of Immunology. 168 (2): 782–92. doi:10.4049/jimmunol.168.2.782. PMID 11777972.
  8. ^ De Witte L; Nabatov A; Pion M; Fluitsma D; De Jong MAWP; De Gruijl T; Piguet V; Van Kooyk Y; Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine. 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373.
  9. ^ Turville S, Wilkinson J, Cameron P, Dable J, Cunningham AL (2003). "The role of dendritic cell C-type lectin receptors in HIV pathogenesis". Journal of Leukocyte Biology. 74 (5): 710–8. doi:10.1189/jlb.0503208. PMID 12960229.

Further reading[edit]

External links[edit]