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Lanicemine ball-and-stick model.png
Systematic (IUPAC) name
Legal status
Legal status
  • Development terminated
CAS Number 153322-05-5
ATC code none
PubChem CID 9794203
ChemSpider 7969970
Chemical data
Formula C13H14N2
Molar mass 198.26 g/mol

Lanicemine (AZD6765) is a low-trapping NMDA receptor antagonist developed by AstraZeneca,[1] which was being studied for the management of severe and treatment-resistant depression.[2] It was originally developed as a neuroprotective agent, but was redeveloped as an antidepressant following the observation that the NMDA receptor antagonist ketamine has potent antidepressant effects, but also has hallucinogenic side effects which make it unsuitable for use as an antidepressant in most circumstances. Lanicemine differs from ketamine in that it is a low-trapping NMDA receptor antagonist, showing similar rapid-acting antidepressant effects to ketamine in clinical trials but with little or no psychotomimetic side effects.[3] However, lanicemine did not meet study endpoints, and its development was terminated by AstraZeneca in 2013.[4]

See also[edit]


  1. ^ US 6518432, Melvyn E. Giles, "Process" 
  2. ^ "AstraZeneca Annual Report and Form 20-F Information 2012" (PDF). 
  3. ^ Zarate, C. A.; Mathews, D.; Ibrahim, L.; Chaves, J. F.; Marquardt, C.; Ukoh, I.; Jolkovsky, L.; Brutsche, N. E.; Smith, M. A.; Luckenbaugh, D. A. (2012). "A Randomized Trial of a Low-Trapping Nonselective N-Methyl-D-Aspartate Channel Blocker in Major Depression". Biological Psychiatry. 74 (4): 257–264. doi:10.1016/j.biopsych.2012.10.019. PMC 3594049free to read. PMID 23206319. 
  4. ^ Flowers, Sophie. "Return to growth: AstraZeneca's CEO Pascal Soriot says 2013 was year of "momentum" for the company". Retrieved 6 February 2014.