From Wikipedia, the free encyclopedia
Jump to: navigation, search
Lansoprazole 3D.png
Systematic (IUPAC) name
Clinical data
Pronunciation /lænˈsprəzl/ lan-SOH-prə-zohl
Trade names Prevacid
AHFS/ Monograph
MedlinePlus a695020
License data
  • AU: B3
  • US: B (No risk in non-human studies)
Routes of
Oral, IV
Legal status
Legal status
  • UK: POM (Prescription only)
  • US: OTC
Pharmacokinetic data
Bioavailability 80% or more
Protein binding 97%
Metabolism Hepatic (CYP3A4- and CYP2C19-mediated)
Biological half-life 1–1.5 hours
Excretion Renal and fecal
CAS Number 103577-45-3 YesY
ATC code A02BC03 (WHO)
PubChem CID 3883
DrugBank DB00448 YesY
ChemSpider 3746 YesY
KEGG D00355 YesY
Chemical data
Formula C16H14F3N3O2S
Molar mass 369.363 g/mol
Chirality Racemic mixture

Lansoprazole is a proton-pump inhibitor (PPI) which inhibits the stomach's production of gastric acids. It is manufactured by a number of companies worldwide under several brand names. In the United States, it was first approved by the Food and Drug Administration (FDA) in 1995.[1] Prevacid patent protection expired on November 10, 2009.[2][3] There is not evidence that its effectiveness is different than that of other PPIs.[4]

Lansoprazole is a proton-pump inhibitor (PPI) in the same pharmacologic class as omeprazole. Lansoprazole has been marketed for many years and is one of several PPIs available.[5] It is a racemic 1:1 mixture of the enantiomers dexlansoprazole (Dexilant, formerly named Kapidex) and levolansoprazole.[6] Dexlansoprazole is an enantiomerically pure active ingredient of a commercial drug as a result of the enantiomeric shift.

Lansoprazole's plasma elimination half-life (1.5 h) is not proportional to the duration of the drug's effects to the person (i.e. gastric acid suppression).[7] and the effects of the drug last for over 24 hours after it has been used for a day or more.[8] Lansoprazole, given nasogastrically, effectively controls intragastric pH and is an alternative to intravenous pantoprazole in people who are unable to swallow solid-dose formulations.[9]

Medical uses[edit]

Lansoprazole is used for treatment of:

There is no good evidence that it works better than other PPIs.[4]

Side effects[edit]

Side effects of PPIs in general[10] and lansoprazole in particular[11] may include:

PPIs may be associated with a greater risk of hip fractures and Clostridium difficile-associated diarrhea.[8]:22


Lansoprazole interacts with several other drugs, either due to its own nature or as a PPI.[15]

Lansoprazole possibly interacts with, amongst other drugs:


Prevacid 30 mg

The lansoprazole molecule is off-patent and so generic drugs are available under many brand names in many countries;[17] there are patents covering some formulations in effect as of 2015.[18]

Since 2009, lansoprazole has been available over the counter (OTC) in the U.S. in a marketed by Novartis as Prevacid 24HR.[19][8][20] In Australia, it is marketed by Pfizer as Zoton.


In vitro experiments have shown that lansoprazole binds to the pathogenic form of tau protein.[21] As of 2015 laboratory studies were underway on analogs of lansoprazole to explore their use as potential PET imaging agents for diagnosing tauopathies including Alzheimer's disease.[21] Lansoprazole is also a prodrug that targets the cytochrome bc1 complex of Mycobacterium tuberculosis once converted to lansoprazole sulfide in mycobacterial host cells.[22]


  1. ^ Mosby's Drug Consult: Lansoprazole
  2. ^ Prevacid drug patents
  3. ^ Teva to release Prevacid version when patent expires
  4. ^ a b "[99] Comparative effectiveness of proton pump inhibitors | Therapeutics Initiative". 28 June 2016. Retrieved 14 July 2016. 
  5. ^
  6. ^ "Pharmacy Benefit Update". Retrieved 2 July 2014. 
  7. ^ "Prevacid Pharmacology, Pharmacokinetics, Studies, Metabolism". 2007. Retrieved April 14, 2007. 
  8. ^ a b c d "Prevacid 24HR Label" (PDF). May 2010. Retrieved November 15, 2014. 
  9. ^ Freston, James; Chiu, Yi-Lin; Pan, Wei-Jian; Lukasik, Nancy; Taubel, Jorg (2001). "Effects on 24-hour intragastric pH: a comparison of lansoprazole administered nasogastrically in apple juice and pantoprazole administered intravenously". The American Journal of Gastroenterology. 96 (7): 2058–2065. doi:10.1111/j.1572-0241.2001.03939.x. ISSN 0002-9270. PMID 11467632. 
  10. ^ British National Formulary (Free registration required) 1.3.5 Proton pump inhibitors
  11. ^ British National Formulary (Free registration required) Lansoprazole
  12. ^ "Prevacid (Lansoprazole) Drug Information: Side Effects and Drug Interactions - Prescribing Information at RxList". RxList. Retrieved 2016-02-09. 
  13. ^ K C Singhal & S Z Rahman, Lansoprazole Induced Adverse Effects on the Skin, Indian Medical Gazette, July 2001, Vol. CXXXV. N0. 7: 223-225
  14. ^ Sterry W, Assaf C (2007). "Erythroderma". In Bolognia JL. Dermatology. St. Louis: Mosby. p. 154. ISBN 1-4160-2999-0. .
  15. ^ British National Formulary (Free registration required) Lansoprazole interactions
  16. ^ Piscitelli, S. C.; Goss, T. F.; Wilton, J. H.; d'Andrea, D. T.; Goldstein, H; Schentag, J. J. (1991). "Effects of ranitidine and sucralfate on ketoconazole bioavailability". Antimicrobial Agents and Chemotherapy. 35 (9): 1765–1771. PMC 245265free to read. PMID 1952845. 
  17. ^ International availability of lansoprazole Page accessed February 3, 2015
  18. ^ Generic lansoprazole Page accessed February 3, 2015
  19. ^ "Novartis launches Prevacid 24HR over-the-counter for full 24-hour frequent heartburn treatment" (PDF) (Press release). November 12, 2009. Retrieved November 13, 2009. 
  20. ^ "Novartis launches Prevacid 24HR over-the-counter for full 24-hour frequent heartburn treatment" (Press release). November 12, 2009. Retrieved November 13, 2009. 
  21. ^ a b Villemagne, VL; Fodero-Tavoletti, MT; Masters, CL; Rowe, CC (January 2015). "Tau imaging: early progress and future directions.". The Lancet. Neurology. 14 (1): 114–24. doi:10.1016/s1474-4422(14)70252-2. PMID 25496902. 
  22. ^ Rybniker, Jan; et al. (July 2015). "Lansoprazole is an antituberculous prodrug targeting cytochrome bc1". Nature Communications. 6: 7659. doi:10.1038/ncomms8659. PMC 4510652free to read. PMID 26158909. 

External links[edit]