Latrophilin 3

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ADGRL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADGRL3, CIRL3, LEC3, CL3, LPHN3, adhesion G protein-coupled receptor L3
External IDsOMIM: 616417 MGI: 2441950 HomoloGene: 22878 GeneCards: ADGRL3
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ADGRL3
Genomic location for ADGRL3
Band4q13.1Start61,201,258 bp[1]
End62,078,335 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 4: 61.2 – 62.08 MbChr 5: 81.02 – 81.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.[5][6]

Function[edit]

This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.[6]

Clinical significance[edit]

A version of this gene has been linked to attention deficit hyperactivity disorder (ADHD).[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150471 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037605 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–31. doi:10.3109/10799890009150640. PMID 10994649. S2CID 19919738.
  6. ^ a b "Entrez Gene: LPHN3 latrophilin 3".
  7. ^ Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, et al. (Nov 2010). "A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts the effectiveness of stimulant medication" (PDF). Molecular Psychiatry. 15 (11): 1053–66. doi:10.1038/mp.2010.6. PMID 20157310.[permanent dead link]

Further reading[edit]

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Adhesion G protein-coupled receptor L3
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L3


This article incorporates text from the United States National Library of Medicine, which is in the public domain.