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They had two children: a daughter, Nella (1931–1995), and a son, Giulio (1936–1997), named after Enrico's older brother, who had died in 1915.
In 1938, the Fermis emigrated to the United States to escape the politics of the Fascist government of Benito Mussolini; Laura was Jewish. They traveled to Stockholm to receive Fermi's Nobel prize, and left from Stockholm for the United States. They were naturalized as Americans in 1944.
After Enrico died of stomach cancer in 1954, Laura became a writer and a peace activist. She published a book about her life with Enrico, Atoms in the Family, the same year he died. She herself died in 1977.
- Atoms in the Family: My Life with Enrico Fermi (University of Chicago Press, 1954) ISBN 0-88318-524-5
- "Atoms for the World: United States participation in the Conference on the Peaceful uses of Atomic Energy"(University of Chicago Press, 1957) ISBN 0-88318-524-5
- "Mussolini" (University of Chicago Press, 1961)
- "The Story of Atomic Energy" (Random House, 1961)
- "Galileo and the Scientific Revolution" (with Gilberto Bernardini) (Basic Books, 1961) ISBN 0-486-43226-2
- "Illustrious Immigrants: The Intellectual Migration from Europe 1930–41 (University of Chicago Press, 1968) ISBN 0-226-24378-8
- Joseph D. Zund. "Fermi, Enrico" American National Biography Online Feb. 2000, Access Date: Mon Oct 10 2005
- Time 100: Enrico Fermi