Le Vésinet-Centre is on the A1 branch of the RER A. Therefore, westbound services always terminate at Saint-Germain-en-Laye whilst eastbound ones travel to downtown Paris and Boissy-Saint-Léger on the A2 branch. Passengers must switch at Vincennes for trains to Marne-la-Vallée - Chessy on the A4 branch. In general, evening service arrives every 15 minutes, off-peak service arrives at 10-minute intervals, and at peak hours trains come every six minutes.
The station is in zone 4 of the RATP fare zone system. A ticket for any station outside of this zone increases based on the number of zones travelled. Thus, whilst a ticket to any station in zone 4 is only €1.50, a ticket to zone 1 (equivalent of central Paris) costs €3.60.