Lecithin–cholesterol acyltransferase

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LCAT
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LCAT, entrez:3931
External IDs OMIM: 606967 MGI: 96755 HomoloGene: 68042 GeneCards: LCAT
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000229

NM_008490

RefSeq (protein)

NP_000220

NP_032516.2
NP_032516

Location (UCSC) Chr 16: 67.94 – 67.94 Mb Chr 8: 105.94 – 105.94 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Lecithin–cholesterol acyltransferase (LCAT, also called phosphatidylcholine–sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) and low-density lipoproteins in the blood plasma.[3] LCAT deficiency can cause impaired vision due to cholesterol corneal opacities, anemia, and kidney damage.[4]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
|px|alt=Statin Pathway edit]]
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

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