Lecithin retinol acyltransferase

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LRAT
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LRAT, LCA14, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
External IDs MGI: 1891259 HomoloGene: 3483 GeneCards: LRAT
RNA expression pattern
PBB GE LRAT 220317 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301645
NM_004744

NM_023624

RefSeq (protein)

NP_001288574
NP_004735

NP_076113.1

Location (UCSC) Chr 4: 154.63 – 154.75 Mb Chr 3: 82.89 – 82.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.[3][4]

Function[edit]

Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver.

Clinical significance[edit]

Mutations in this gene have been associated with early-onset severe retinal dystrophy.[4]

LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D (Feb 1999). "Molecular and biochemical characterization of lecithin retinol acyltransferase". J Biol Chem. 274 (6): 3834–41. doi:10.1074/jbc.274.6.3834. PMID 9920938. 
  4. ^ a b "Entrez Gene: LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)". 
  5. ^ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. 9: e90776. doi:10.1371/journal.pone.0090776. PMC 3946526Freely accessible. PMID 24608339. 

Further reading[edit]

External links[edit]