Melchionni was a high honorable mention All-American in the 2001–02 and a high honorable mention McDonald's All-America. He was a two-time all-state selection (2001–2002), three-time all-county selection and two-time all-city selection. He was the MVP of the 2002 Prime Time Shootout. During his senior year at Germantown Academy in Fort Washington, Pennsylvania he averaged 19.7 points, 9.2 rebounds, 5.0 assists, and 3.0 steals. Melchionni finished with over 1200 points and 800 rebounds. He also averaged 16 points, a team-best 9.0 rebounds, 4.0 assists and 4.0 steals as a junior. He helped lead Germantown to a 27-3 record and a number 17 national ranking by USA Today in 2000-01. He averaged 12.0 points,6.0 rebounds and 2.0 rebounds as a sophomore and averaged 10.0 points, 5.0 rebounds and 2.0 assists as a freshman.
Melchionni spent a single season playing professionally in Italy for Cimberio Novara in the Italian 2nd division. Melchionni is now working as an NBA Player Agent for Wasserman Media Group, representing players like Danilo Gallinari. Melchionni is also enrolled in evening law school at Loyola Law School. Melchionni is now a sports agent. 
Melchionni was born in Lancaster, Pennsylvania. His father, Gary Melchionni played basketball with Duke and was team captain. Gary was also an All-ACC performer and was drafted by the Phoenix Suns in the 2nd Round of the 1973 NBA draft. His uncle, Bill Melchionni played college basketball with Villanova while in college and played with the Philadelphia 76ers and New Jersey Nets while playing in the NBA. Melchionni's younger brother, Dean Melchionni, is currently a basketball player at the University of Texas. 
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- "Ex-Duke player Melchionni takes on new challenge". News & Record. June 22, 2008. Retrieved January 18, 2010.
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- Schlabach, Mark (March 10, 2005). "Melchionni Gets Boost by Dropping Depth Charge". The Washington Post. Retrieved 23 November 2009.
- "Texas Longhorns Men's Basketball". CBS Sports. Retrieved April 30, 2013.