Left shift (medicine)
The standard definition of a left shift is an absolute band form count greater than 700/microL. There are competing explanations for the origin of the phrase "left shift," including the left-most button arrangement of early cell sorting machines and a 1920s publication by Josef Arneth, containing a graph in which immature neutrophils, with fewer segments, shifted the median left.
It is usually noted on microscopic examination of a blood smear. This systemic effect of inflammation is most often seen in the course of an active infection and during other severe illnesses such as hypoxia and shock. Döhle bodies may also be present in the neutrophil's cytoplasm in the setting of sepsis or severe inflammatory responses.
- Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004). Robbins & Cotran Pathologic Basis of Disease (7th ed.). Philadelphia, PA: Saunders. pp. 84–85. ISBN 978-0-7216-0187-8.
- Rodak, Bernadette F.; Fritsma, George A.; Doig, Kathryn (2007). Hematology: clinical principles and applications (3rd ed.). Elsevier Health Sciences. p. 171. ISBN 978-1-4160-3006-5.
- Coates, Thomas D (December 22, 2008), "Approach to the patient with neutrophilia", UpToDate Online, 17.3, Wolters Kluwer, retrieved December 21, 2009
- Rodak, B.F.; Fritsma, G.A.; Keohane, E. (2012). Hematology: Clinical Principles and Applications, 4th Ed. Saunders. p. 205. ISBN 978-1437706925. Retrieved 14 Apr 2015.
- Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004). Robbins & Cotran Pathologic Basis of Disease (7th ed.). Philadelphia, PA: Saunders. pp. 663–664. ISBN 978-0-7216-0187-8.