Lengsin

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LGSN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLGSN, GLULD1, LGS, lengsin, lens protein with glutamine synthetase domain
External IDsOMIM: 611470 MGI: 2672844 HomoloGene: 9569 GeneCards: LGSN
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for LGSN
Genomic location for LGSN
Band6q12Start63,275,951 bp[1]
End63,319,983 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001143940
NM_016571

NM_153601

RefSeq (protein)

NP_001137412
NP_057655

NP_705829

Location (UCSC)Chr 6: 63.28 – 63.32 MbChr 1: 31.18 – 31.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lengsin is a protein that in humans is encoded by the LGSN gene.

Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific, noncatalytic role in the lens of the vertebrate eye.[5] Lengsin is the result of the recruitment of an ancient enzyme may act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. It does not seem to have enzymatic activity.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146166 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050217 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wyatt K, Gao C, Tsai JY, Fariss RN, Ray S, Wistow G (March 2008). "A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens". The Journal of Biological Chemistry. 283 (10): 6607–15. doi:10.1074/jbc.M709144200. PMC 2911820. PMID 18178558.

Further reading[edit]

External links[edit]