|Systematic (IUPAC) name|
|CAS Registry Number|
|Molecular mass||426.853 g/mol|
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Lenvatinib showed promising results in a phase I clinical trial in 2006 and is being tested in several phase II trials as of October 2011[update], for example against hepatocellular carcinoma. After a phase II trial testing the treatment of thyroid cancer was completed with modestly encouraging results, the manufacturer launched a phase III trial in March 2011.The FDA has granted approval to lenvatinib (Lenvima) as a treatment for patients with progressive, radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC).
- Matsui, J.; Funahashi, Y.; Uenaka, T.; Watanabe, T.; Tsuruoka, A.; Asada, M. (2008). "Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase". Clinical Cancer Research 14 (17): 5459–65. doi:10.1158/1078-0432.CCR-07-5270. PMID 18765537.
- "Phae III trial shows lenvatinib meets primary endpoint of progression free surival benefit in treatment of radioiodine-refactory differentiated thyroid cancer" (PDF). Eisai. 3 February 2014.
- Glen, H; D. Boss; T. R. Evans; M. Roelvink; J. M. Saro; P. Bezodis; W. Copalu; A. Das; G. Crosswell; J. H. Schellens (2007). "A phase I dose finding study of E7080 in patients (pts) with advanced malignancies". Journal of Clinical Oncology, ASCO Annual Meeting Proceedings Part I 25 (18S): 14073.
- Clinical trial number NCT00946153 for "Study of E7080 in Patients With Advanced Hepatocellular Carcinoma (HCC)" at ClinicalTrials.gov
- Gild, M. L.; Bullock, M.; Robinson, B. G.; Clifton-Bligh, R. (2011). "Multikinase inhibitors: A new option for the treatment of thyroid cancer". Nature Reviews Endocrinology 7 (10): 617–624. doi:10.1038/nrendo.2011.141. PMID 21862995.
- Clinical trial number NCT01321554 for "A Trial of E7080 in 131I-Refractory Differentiated Thyroid Cancer" at ClinicalTrials.gov
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