Leopoldina is a municipality in the Brazilian state of Minas Gerais. As of 2010 , it has a population of 51,136.
It is situated in the southeastern Zona da Mata mesoregion of the state.
The municipality contains the 368.7 hectares (911 acres) Lapinha Biological Reserve, a strictly-protected area of Atlantic Forest.
Leopoldina was the site of a wave of immigration of Jews, mostly from Eastern Europe, in the 1920s and 1930s, as detailed in a book Jews of Leopoldina, published in 2007 by the Jewish Museum of Rio de Janeiro. 
The city is also the seat of the Roman Catholic Diocese of Leopoldina.