Leukemia inhibitory factor receptor

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Available structures
PDB Ortholog search: PDBe RCSB
Aliases LIFR, CD118, LIF-R, SJS2, STWS, SWS, leukemia inhibitory factor receptor alpha, LIF receptor alpha
External IDs OMIM: 151443 MGI: 96788 HomoloGene: 1735 GeneCards: LIFR
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for LIFR
Genomic location for LIFR
Band 5p13.1 Start 38,474,963 bp[1]
End 38,608,354 bp[1]
RNA expression pattern
PBB GE LIFR 205876 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 38.47 – 38.61 Mb Chr 5: 7.13 – 7.2 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.

The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.[5]


Leukemia inhibitory factor receptor has been shown to interact with Glycoprotein 130.[6][7]

LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway. LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool.

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113594 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054263 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: LIFR leukemia inhibitory factor receptor alpha". 
  6. ^ Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G (Jun 2002). "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor". Eur. J. Biochem. Germany. 269 (11): 2716–26. doi:10.1046/j.1432-1033.2002.02941.x. ISSN 0014-2956. PMID 12047380. 
  7. ^ Mosley, B; De Imus C; Friend D; Boiani N; Thoma B; Park L S; Cosman D (Dec 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. UNITED STATES. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. ISSN 0021-9258. PMID 8999038. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.