Lev's disease

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Lev's disease

Lev's disease (or Lenegre-Lev syndrome) is an acquired complete heart block due to idiopathic fibrosis and calcification of the electrical conduction system of the heart. Lev's disease is most commonly seen in the elderly, and is often described as senile degeneration of the conduction system.

One form has been associated with SCN5A.[1]

Associated conditions[edit]

Stokes-Adams attacks can be precipitated by this condition. These involve a temporary loss of consciousness resulting from marked slowing of the heart when the atrial impulse is no longer conducted to the ventricles. This should not be confused with the catastrophic loss of heartbeat seen with ventricular fibrillation or asystole.


It was described independently by Maurice Lev and Jean Lenègre in 1964,[2][3] but the condition is generally called after Lev.

See also[edit]


  1. ^ Schott JJ, Alshinawi C, Kyndt F, et al. (1999). "Cardiac conduction defects associate with mutations in SCN5A". Nat. Genet. 23 (1): 20–1. doi:10.1038/12618. PMID 10471492.
  2. ^ Lev M. Anatomic basis for atrioventricular block. Am J Med 1964;37:742-8. PMID 14237429.
  3. ^ Lenegre J. Etiology and pathology of bilateral bundle branch block in relation to complete heart block. Prog Cardiovasc Dis 1964;6:409-444. PMID 14153648.

External links[edit]