Lewy bodies are abnormal aggregates of protein that develop inside nerve cells in Parkinson's disease (PD), Lewy body dementia, and some other disorders. They are identified under the microscope when histology is performed on the brain.
Lewy bodies appear as spherical masses that displace other cell components. Lewy bodies may be found in the brainstem (within the Substantia Nigra) or within the cortex. A classical Lewy body is an eosinophilic cytoplasmic inclusion consisting of a dense core surrounded by a halo of 10-nm-wide radiating fibrils, the primary structural component of which is alpha-synuclein. Cortical Lewy bodies are also composed of alpha-synuclein fibrils, but are less defined and lack halos. In histopathology, Cortical Lewy bodies are a distinguishing feature for dementia with Lewy bodies (DLB), but may occasionally be seen in ballooned neurons characteristic of Pick's disease and corticobasal degeneration, as well as in patients with other tauopathies. They are also seen in cases of multiple system atrophy, particularly the Parkinsonian variant.
Lewy bodies were discovered by Frederic Lewy in 1912.
A Lewy body is composed of the protein alpha-synuclein associated with other proteins, such as ubiquitin, neurofilament protein, and alpha B crystallin. Tau proteins may also be present, and Lewy bodies may occasionally be surrounded by neurofibrillary tangles. Lewy bodies and NFTs can occasionally exist in the same neuron, particularly in the amygdala.
Lewy neurites are abnormal neurites in diseased neurons, containing granular material and abnormal α-synuclein filaments similar to those found in Lewy bodies. Like Lewy bodies, lewy neurites are a feature of α-synucleinopathies such as dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. They are also found in the CA2-3 region of the hippocampus in Alzheimer's disease.
Notable people who suffered from Lewy body dementia include:
- Actor Robin Williams
- Actress Estelle Getty
- Music industry icon Casey Kasem
- Athlete Stan Mikita
- Artist Don Featherstone, creator of the iconic lawn flamingo.
- Former NBA head coach Jerry Sloan
- In the premiere episode of Boss, Dr. Ella Harris tells Chicago Mayor Tom Kane he has Lewy bodies, and his progressing symptoms are shown in each episode.
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