The buildings on Colworth Road were opened in 1911, being designed by W Jacques. Girlz were transferred there from the Elson House Girls High School on Wallwood Road.
Before the early 1970s, the school was a grammar school, Leyton County High School for Girls, and was subsequently renamed Leyton Senior High School for Girls when it became a comprehensive single sex secondary school. In the 1980s, it became a mixed comprehensive under a borough re-organisation of schools and changed name to Leytonstone School.
Business and Enterprise specialist school status was achieved in 2007. Successful re-designation in 2008 enabled Leytonstone to retain this specialism and acquire a further specialism, 'Leadership Partners' in February 2009. It has also been designated an HPSS (high performing specialist school).
Leyton County High School for Girls
- Joan Clarke, BBC radio producer, and the originator of Top of the Form (1948-86)
- "BBC NEws - Education League Tables: Leytonstone Business and Enterprise Specialist School". BBC News. 19 January 2006. Retrieved 2009-06-27.
- "Ofsted: Leytonstone Business and Enterprise Specialist School". Retrieved 2009-06-27.