Licochalcone A

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Licochalcone A
Chemical structure of licochalcone A
Names
IUPAC name
(E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
Other names
Licochalcone a
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.163.544
Properties
C21H22O4
Molar mass 338.39 g/mol
Hazards
R-phrases (outdated) R20, R21, R22
S-phrases (outdated) S36
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Licochalcone A is a chalconoid, a type of natural phenols. It can be isolated from root of Glycyrrhiza glabra[1] (liquorice) or Glycyrrhiza inflata.[2] It shows antimalarial, anticancer, antibacterial and antiviral (specifically against influenza neuraminidase) properties in vitro.[1][2][3][4]


References[edit]

  1. ^ a b Fu, Y.; Hsieh, T. C.; Guo, J.; Kunicki, J.; Lee, M. Y. W. T.; Darzynkiewicz, Z.; Wu, J. M. (2004). "Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells". Biochemical and Biophysical Research Communications. 322 (1): 263–270. PMID 15313200. doi:10.1016/j.bbrc.2004.07.094. 
  2. ^ a b Friis-Møller, A.; Chen, M.; Fuursted, K.; Christensen, S. R. B. G.; Kharazmi, A. (2002). "In Vitro Antimycobacterial and Antilegionella Activity of Licochalcone a from Chinese Licorice Roots". Planta Medica. 68 (5): 416–419. PMID 12058317. doi:10.1055/s-2002-32087. 
  3. ^ Chen, M.; Theander, T. G.; Christensen, S. B.; Hviid, L.; Zhai, L.; Kharazmi, A. (1994). "Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. Yoelii infection". Antimicrobial Agents and Chemotherapy. 38 (7): 1470–1475. PMC 284578Freely accessible. PMID 7979274. doi:10.1128/aac.38.7.1470. 
  4. ^ Dao, TT; Nguyen, PH; Lee, HS; Kim, E; Park, J; Lim, SI; Oh, WK (January 2011). "Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata.". Bioorganic & Medicinal Chemistry Letters. 21 (1): 294–8. PMID 21123068. doi:10.1016/j.bmcl.2010.11.016.