Lidoflazine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Lidoflazine
Lidoflazine.png
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ECHA InfoCard 100.020.285
Chemical and physical data
Formula C30H35F2N3O
Molar mass 491.615 g/mol
3D model (Jmol)
Melting point 159 to 161 °C (318 to 322 °F)
Solubility in water Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C)
 NYesY (what is this?)  (verify)

Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.

Physical properties[edit]

Solubility at room temperature[edit]

Extracted from [2]

Solvent 0.01

N

0.1

N

 % pH  % pH
Hydrochloric Acid 0.4 3.0 0.7 1.9
Tartaric Acid 0.3 3.1 1.0 2.5
Citric Acid 0.3 3.1 0.5 2.5
Lactic Acid 0.2 3.4 0.7 2.9
Acetic Acid 0.1 3.5 0.4 3.8

References[edit]

  1. ^ Schaper, W.K.A.; Xhonneux, R.; Jageneau, A.H.M.; Janssen, P.A.J. (1966). "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator". Journal of Pharmacology and Experimental Therapeutics. 152 (2): 265–274. PMID 5944369. Retrieved 2009-06-20. 
  2. ^ http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265
  • Schaper WK, Xhonneux R, Jageneau AH., Stimulation of the coronary collateral circulation by lidoflazine (R 7904), Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 November 4;252(1):1-8.