Lidoflazine
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| ECHA InfoCard | 100.020.285 |
| Chemical and physical data | |
| Formula | C30H35F2N3O |
| Molar mass | 491.615 g/mol g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 159 to 161 °C (318 to 322 °F) |
| Solubility in water | Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C) |
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Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.
Physical properties
Solubility at room temperature
Extracted from [2]
| Solvent | 0.01
N |
0.1
N | ||
| % | pH | % | pH | |
| Hydrochloric Acid | 0.4 | 3.0 | 0.7 | 1.9 |
| Tartaric Acid | 0.3 | 3.1 | 1.0 | 2.5 |
| Citric Acid | 0.3 | 3.1 | 0.5 | 2.5 |
| Lactic Acid | 0.2 | 3.4 | 0.7 | 2.9 |
| Acetic Acid | 0.1 | 3.5 | 0.4 | 3.8 |
References
- ^ Schaper, W.K.A.; Xhonneux, R.; Jageneau, A.H.M.; Janssen, P.A.J. (1966). "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator". Journal of Pharmacology and Experimental Therapeutics. 152 (2): 265–274. PMID 5944369. Retrieved 2009-06-20.
- ^ http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265
- Schaper WK, Xhonneux R, Jageneau AH., Stimulation of the coronary collateral circulation by lidoflazine (R 7904), Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 November 4;252(1):1-8.
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