Lipozene is a brand name dietary supplement sold by Obesity Research Institute, LLC. The primary ingredient in Lipozene is glucomannan.
Lipozene contains a single ingredient, glucomannan, a water-soluble, fermentable dietary fiber extracted from the tuber or root of the elephant yam, also known as Konjac (Amorphophallus konjac or A. rivieri).
Clinical trials examining the use of glucomannan for weight loss have produced mixed results. A 2014 systematic review and meta-analysis of clinical trials failed to show that glucomannan supplementation generated statistically significant weight loss. Obesity Research Foundation, LLC was fined $1.5 million by the Federal Trade Commission in 2005 for misleading statements about weight-loss results from a similar glucomannan-containing product.
- Keithley,J., Swanson, B., Mikolaitis, M., DeMeo, J., Zeller, L., Fogg, Adamji, J. 2013. Safety and Efficacy of Glucomannan for Weight Loss in Overweight and Moderately Obese Adults. J Obes. 2013; 2013: 610908
- Salas-Salvadó J, Farrés X, Luque X, Narejos S, Borrell M, Basora J, Anguera A, Torres F, Bulló M, Balanza R (2008). "Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial". Br J Nutr. 99 (6): 1380–7. doi:10.1017/S0007114507868528. PMID 18031592.
- Onakpoya I, Posadzki P, Ernst E (February 2014). "The efficacy of glucomannan supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials". Journal of the American College of Nutrition. 33 (1): 70–8. doi:10.1080/07315724.2014.870013. PMID 24533610.
- "FTC Settles Claims with Marketers of FiberThin and Propolene". Federal Trade Commission (Press release). June 20, 2005. Retrieved November 23, 2017.