Liquid paraffin (drug)

From Wikipedia, the free encyclopedia
  (Redirected from Liquid paraffin (medicinal))
Jump to navigation Jump to search
Liquiduim paraffinium
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Topical, oral
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem SID
ChemSpider
  • none
ECHA InfoCard100.029.438 Edit this at Wikidata
Chemical and physical data
FormulaC
n
H
2n+2

Liquid paraffin, also known as paraffinum liquidum, is a very highly refined mineral oil used in cosmetics and for medical purposes. This is a UK definition (British Pharmacopoeia) and the term may have different uses in other countries. The cosmetic or medicinal liquid paraffin should not be confused with the paraffin (or kerosene) used as a fuel.

The term paraffinum perliquidum is sometimes used to denote light liquid paraffin. Conversely, the term paraffinum subliquidum is sometimes used to denote a thicker mineral oil.

Usage and side effects orally as laxative[edit]

Liquid paraffin is considered to have a limited usefulness as an occasional laxative, but is unsuitable for regular use as it can seep from the anus and cause irritation.[citation needed]

Efficacy of liquid paraffin is suggested by 2016 Cochrane review.[1]

It might interfere with the absorption of fat-soluble vitamins, though evidences seem low.[2]

It can be absorbed into the intestinal wall[citation needed], and may cause foreign-body granulomatous reactions in some rat species but not in others and that reaction might not occur with human.[3]

There are evidences suggesting the lack of carcinogenicity.[4]

If it enters the lungs, it can cause lipoid pneumonia.[5]

Liquid paraffin is also used in combination with magnesium as an osmotic laxative, sold under the trade name Mil-Par (among others).[6]

Side effects if injected[edit]

Causes granulomatous reactions if injected.[7]

See also[edit]

References[edit]

  1. ^ Gordon, Morris; MacDonald, John K.; Parker, Claire E.; Akobeng, Anthony K.; Thomas, Adrian G. (2016-08-17). "Osmotic and stimulant laxatives for the management of childhood constipation". The Cochrane Database of Systematic Reviews (8): CD009118. doi:10.1002/14651858.CD009118.pub3. ISSN 1469-493X. PMID 27531591.
  2. ^ Gal-Ezer, Sharon; Shaoul, Ron (November 2006). "The safety of mineral oil in the treatment of constipation--a lesson from prolonged overdose". Clinical Pediatrics. 45 (9): 856–858. doi:10.1177/0009922806295285. ISSN 0009-9228. PMID 17041175.
  3. ^ Fleming, null; Zimmerman, null; Shubik, null (February 1998). "Granulomas in the livers of humans and fischer rats associated with the ingestion of mineral hydrocarbons: A comparison". Regulatory toxicology and pharmacology. 27 (1 Pt 2): 75–81. doi:10.1006/rtph.1997.1109. ISSN 1096-0295. PMID 9618325.
  4. ^ Shoda, T.; Toyoda, K.; Uneyama, C.; Takada, K.; Takahashi, M. (December 1997). "Lack of carcinogenicity of medium-viscosity liquid paraffin given in the diet to F344 rats". Food and Chemical Toxicology. 35 (12): 1181–1190. ISSN 0278-6915. PMID 9449224.
  5. ^ Alan Nathan. Non-prescription medicines. London: Pharmaceutical Press; 2006 [cited October 8, 2011]. ISBN 978-0-85369-644-5. p. 68.
  6. ^ "Magnesium & Liquid Paraffin". Patient UK.
  7. ^ Sejben, István; Rácz, András; Svébis, Mihály; Patyi, Márta; Cserni, Gábor (August 2012). "Petroleum jelly-induced penile paraffinoma with inguinal lymphadenitis mimicking incarcerated inguinal hernia". Canadian Urological Association Journal = Journal De l'Association Des Urologues Du Canada. 6 (4): E137–139. doi:10.5489/cuaj.11146. ISSN 1920-1214. PMC 3430719. PMID 23093564.